Research Scientist, In Vivo Pharmacology at Takeda Pharmaceutical

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

Research Scientist, In Vivo Pharmacology, GI2

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as an Research Scientist, In Vivo Pharmacology. You will have experience in inflammatory disease, fibrotic and extra-cellular matrix pathobiology, innate and adaptive cell biology and associated in vivo models of disease to join the Gastro-Intestinal Inflammation Research (Drug Discovery Unit).

You will possess strong technical skills and primarily be responsible for in vivo experiments with associated ex vivo analysis to further biological understanding and enable a translational medicine strategy for inflammatory / fibrotic diseases of the gastro-intestinal tract and hepato-biliary system. You may also have the opportunity to perform for in vitro experiments. As you grow within the team, you will also execute in vivo models of skin, lung and joint inflammation.

You will support a broad pipeline in autoimmune and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules from multiple modalities (biologics, small molecules, nucleic acids and cellular therapies).

How you will contribute:

• Proper handling and care of mice and other rodents, general dosing (multiple routes – oral, IV, IP, SC) and surgical techniques and collection and analysis of blood and tissue samples ; work schedule flexibility to ensure optimal dosing schedules on a project specific need will be required on a case by case basis.
• Understands and implements study protocols in accordance with regulatory requirements for compliance with IACUC guidelines – ability to write IACUC protocols for new models of disease.
• Independently design and execute in vivo experiments, analyze data and interpret results and present data to relevant stakeholders: Knowledge of data analysis programs such as GraphPad PRISM, MicroSoft Excel Fit, FlowJo FACS analysis, Nanostring transcriptome analysis and Softmax Pro and/or other equivalent software.
• Maintenance of electronic laboratory notebooks and technical reports to support regulatory submissions as needed.
• Developing and optimizing project specific mechanistically relevant short term pathway activation as well as disease mouse models of disease - subsequent analysis of PK/PD and associated disease-related pathologies by various techniques such as flow cytometry, histology, protein multiplex ELISAs and focused or full transcriptome / proteome analysis.
• Troubleshooting methodological and technical issues, interpreting experimental data and literature and communicating results to diverse groups of individuals.
• Contributing to lab and equipment maintenance and order supplies/reagents to help build a safe, effective and efficient working environment.
• Collaborates and communicates effectively with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts.

Minimum Requirements/Qualifications:

• PhD degree in a scientific discipline (or equivalent), or
• MS with 6+ years relevant experience, or BS with 8+ years relevant experience
• You will have a passion for innovation and desire to lead new scientific directions, being a standout colleague with a collaborative spirit, excellent communication, organization, and time management skills and confident with multitasking and managing multiple projects simultaneously.

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

U.S. Base Salary Range:

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time