Scientist, Off-Target Characterization and Assay Development at Intellia Therapeutics

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We wantall ofour people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:
We are looking to hire a highly motivated Scientist to the Genomics Innovation team! As a Scientist, you will help support the characterization and quantitation of unintended off-target genome editing with CRISPR/Cas9 using high throughput next generation sequencing (NGS). You will:

• Develop, conduct and evaluate genome-wide off-target experiments to characterize guides for therapeutic development.

• Troubleshoot and support new project needs as the NGS assay expert independently and in collaboration with colleagues.

• Lead and manage projects for evaluation of off-target methods with CROs.

• Collaborate with computational biology team to assess data quality, support data interpretation, and aid the development of innovative analysis pipelines.

• Accurately report project and sample information, protocols, and experimental details through the Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN)

• Write and review technical and study reports to support regulatory filings (IND or CTA equivalent), and then synthesize the results for effective communication across various levels of expertise.

• Manage and mentor junior scientists within the team.

• Lead complex research assignments (with limited guidance from supervisor), analyze datasets, and present your findings in team meetings.

About you:

The ideal candidate will have a strong background in genomics technology and hands-on experience with developing NGS-based assays, as well as a passion for pushing the boundaries of what is possible in genomics research. We are looking for a candidate with a PhD in Molecular Biology or related discipline, with 1-3 years of relevant experience in academic or industrial setting. If you have strong communications skills (written and oral), coupled with exceptional time management skills and attention to detail, we encourage you to apply!

Meet your future team:

The Genomic Innovation Team is an energetic and passionate group of individuals, who are focused on applications of genomics to advance research and innovation in gene editing. You will report directly to a Principal Scientist in the Genomics Innovation Team. This hiring manager develops and evaluates genomics methods for off-target characterization and supports genotoxicity documentation for Health Authority regulatory interactions. The breadth of exposure to cutting edge gene therapy development will provide the candidate with exposure to the full spectrum of CRISPR therapeutic development in vivo and in cell-based therapies engineered with CRISPR.

The team is working fully onsite to execute NGS workflows in a wet-lab environment. Therefore, we require a candidate to be currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in therapeutic biotechnology. If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient’s lives.

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Covid-19 Vaccination Policy:All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.