Senior Associate Scientist, Molecular Discovery - Pfizer
La Jolla, CA
About the Job
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world. Pfizer BioMedicine Design group at San Diego, CA is seeking an outstanding and highly motivated Senior Associate Scientist with training in protein purification and characterization to join a dynamic team in antibody discovery, optimization, and production. This role requires good understanding and hands-on skills in protein/antibody production and engineering.
What You Will Achieve
As a Senior Associate Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will play an important role in a high-energy protein purification research laboratory. You will be responsible for processing of mammalian-expressed recombinant protein modalities including, but not limited to, monoclonal antibodies using state-of-the-art technologies and equipment. You will also contribute to the group wide deliverables and be required to work on several projects simultaneously presenting results and updates at group meetings.
How You Will Achieve It
Work within a team on various antibody identification, optimization, and/or production projects in parallel.
Implement protein purification methods to isolate IgG, fusion proteins and antigens from mammalian cell culture.
Analyze proteins using standard protein characterization methods (UV, SDS-PAGE/cGE, analytical SEC, SEC-MALS, endotoxin, etc.).
Comfortable working with AKTA
Design experiments, analyze data, and troubleshoot when issues arise, under supervision.
Present experimental design and results at internal meetings.
Accomplish goals under project team timelines.
Qualifications
Must-Have
B.S or M.S in Biological Science (Molecular Biology, Structural Biology, Biochemistry, Cell Biology) or a related field (Chemistry, Chemical Engineering, Biomedical Engineering and Biological Engineering) with 3+ years or M.S with 1-2 years of relevant experience in either an academic or industrial setting
Understand principles and able to execute modern protein purification techniques (protein A/G affinity, Immobilized Metal Chelate Affinity Chromatography (IMAC), size exclusion, ion exchange chromatography).
Previous experience with protein characterization methods, including SDS-PAGE/cGE, aSEC, mass spec, endotoxin measurement.
Detail-oriented, document data and experiments properly, good communication and interpersonal skills.
Ability and desire to work in a fast-paced interdisciplinary scientific team and the desire to learn new techniques.
Strong time management skills and ability to multitask.
Nice-to-Have
Previous experience with protein and/or antibody engineering
Previous experience with molecular cloning techniques and cell culture
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.
Other Job Details:
Last Date to Apply for Job:November 14th, 2024
Work Location Assignment: On Premise
On Premise colleagues work in a Pfizer site because it’s needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.
The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
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