Senior Associate Scientist, Tumor Immunity--non PhD - Pfizer
La Jolla, CA
About the Job
POSITION SUMMARY
Our Tumor Biology group develops biologic therapeutics that promote immune cell engagement with tumor cells in effort to eliminate cancer. As a member of this group, you will support these efforts and be a critical player in the group’s mission by executing wet lab assays that will be used for proof-of-concept testing and lead molecule development. Your work will primarily focus on supporting biology line initiatives and will also involve collaborating with other functional lines in a matrix team environment.
POSITION RESPONSIBILITIES
Execute cell-based functional and biochemical assays to select candidate molecules for clinical development
Plan and execute ex vivo mouse tissue assays, such as multi-color flow cytometry, gene expression analyses, and mammalian cell culture
Analyze, organize, and present results in small and large group meetings
Read relevant scientific literature to aid in experimental design
BASIC QUALIFICATIONS
B.S. degree in Biology or related discipline
3+ years’ of industry experience in immunology, cell biology and/or tumor biology
Experience planning and executing in vitro and/or in vivo/ex vivo experiments with some supervision
Experience with standard immunologic techniques including flow cytometry (8+ parameters)
Experience with cancer cell line culture
Strong verbal and written communication skills
PREFERRED QUALIFICATIONS
M.S. degree in Biology or related discipline
Technical experience with immune cell-based functional assays including human/mouse T cell activation, proliferation, and cytotoxicity assays using T cell engagers
Experience independently phenotyping human and mouse tumor associated T cells from primary human/mouse tumor samples using flow cytometry and conducting related analyses
Experience with molecular techniques including ELISA, qRT-PCR, MSD, and CRISPR-CAS9 gene editing
PHYSICAL/MENTAL REQUIREMENTS
• Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory
• Standard business office conditions; sitting, standing as appropriate
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
• Lifting, sitting, standing, walking, bending, repetitive pipetting, ability to perform mathematical calculations, ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.
• Routine off-hour and weekend schedule
Work Location Assignment: On Premise
The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
