Senior Director, DMPK - Bicycle Therapeutics

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass. 

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

• We are One Team. We only succeed when we work together.  

The Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.   

1. Provide DMPK scientific leadership across all stages of the portfolio.
2. Oversee the quality and performance of all DMPK activities including interactions with external CRO’s and internal project stakeholders.
3. Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
4. Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion.
5. Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
6. Work closely with discovery team and regulatory team to author and review DMPK related IND documents
7. Managing DMPK budgets for CRO’s and monitoring CROs to ensure delivery of quality data on time.
8. Support leadership of the Quantitative Pharmacology group and junior staff development

Essential:  

1. PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
2. Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
3. In depth understanding of DMPK science with additional knowledge of related disciplines.
4. Demonstrated expertise in DMPK problem solving across drug discovery.
5. Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
6. Excellent organisation and communication skills, both written and oral, with the ability to influence.

Desirable:  

1. Previous experience working on peptides-macrocycles would be an advantage.
2. Nice-to-have: experience on radio-pharm projects

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

All your information will be kept confidential according to EEO guidelines.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.