Senior Scientist, Computational Biology / Toxicology at Merck Sharp & Dohme (MSD)
West Point, PA 19486
About the Job
Job DescriptionThe Nonclinical Drug Safety (NDS) division at our company is seeking a motivated Computational Biologist/Toxicologist for our Computational Toxicology group.The successful candidate will have a passion for using computational biology and advanced data science approaches, including artificial intelligence (AI) and machine learning (ML), to inform drug development and safety.Note: This position is available in West Point, PA or South San Francisco, CA.Key Responsibilities: Leverage expertise in computational biology, bioinformatics, and machine learning to create a pipeline for the analysis of multimodal data including but not limited to multi-omics, chemistry, drug metabolism and pharmacokinetics, and in vitro/in vivo toxicology data, aiding in the comprehension of toxicity mechanisms.Lead the development of AI/ML models to construct advanced models for organ-specific toxicity and safety phenotypes across multiple modalities.Work both independently and collaboratively with toxicologists, compound leaders, and assay owners within NDS, as well as researchers from other functional areas outside NDS, to enhance drug safety evaluations within and across multiple projects.Influence the regulatory toxicology landscape through active participation in external consortiums, publications, and presentations at key scientific conferences.Qualifications: Education:Master's (with 4+ years) or Ph.D
in computational biology, bioinformatics, computer science or related data science fields with relevant experience listed belowRequired Experience and Skills:Proven experience in analyzing various data types including transcriptomics, proteomics, metabolomics, molecular, and imaging dataDemonstrable experience applying advanced AI/ML techniques, including but not limited to Deep Neural Network Frameworks, in problem-solving scenariosProficiency in Python, R programming, and ML frameworks such as TensorFlow and PyTorch is essentialExperience with version control systems, such as GIT, and related code reproducibility practices, such as documentation, is requiredExceptional communication, presentation, and interpersonal skills to effectively distill complex technical concepts for a broad range of stakeholders is necessaryA highly self-motivated individual with the ability to work independentlyPreferred Experience and Skills:Proficiency in creating effective visualizations using platforms such as seaborn, matplotlib, ggplot2Experience with high-performance or cloud computing environments (e.g., AWS) and data lake platforms (e.g., Databricks)Prior experience working in a multidisciplinary environment within the Pharmaceutical Industry, Regulatory Agencies, or Academic InstitutionsNOTICEFORINTERNALAPPLICANTSIn accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package
To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.#EligibleforERP #DATA2025Current Employees apply HERECurrent Contingent Workers apply HEREUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities
Please click here if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S
Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA SupplementPay Transparency NondiscriminationWe are proud to be a company that embraces the value of bringing diverse, talented, and committed people together
The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively
Learn more about your rights, including under California, Colorado and other US State ActsU.S
Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S
will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely
Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States
Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.Expected US salary range:$151,900.00 - $239,200.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days
A summary of benefits is listed here.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities
All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company
No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place
Where agency agreements are in place, introductions are position specific
Please, no phone calls or emails. Employee Status: RegularRelocation:Domestic/InternationalVISA Sponsorship:YesTravel Requirements:10%Flexible Work Arrangements:HybridShift:1st - DayValid Driving License:NoHazardous Material(s):NoRequired Skills:Business Intelligence (BI), Database Design, Data Engineering, Data Modeling, Data Science, Data Visualization, Machine Learning, Software Development, Stakeholder Relationship Management, Waterfall Project ManagementPreferred Skills:Job Posting End Date:11/22/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date
Please ensure you apply to a job posting no later than the day BEFORE the job posting end date
SummaryLocation: USA - Pennsylvania - West Point; USA - California - South San Francisco (Grand Ave)Type: Full time
in computational biology, bioinformatics, computer science or related data science fields with relevant experience listed belowRequired Experience and Skills:Proven experience in analyzing various data types including transcriptomics, proteomics, metabolomics, molecular, and imaging dataDemonstrable experience applying advanced AI/ML techniques, including but not limited to Deep Neural Network Frameworks, in problem-solving scenariosProficiency in Python, R programming, and ML frameworks such as TensorFlow and PyTorch is essentialExperience with version control systems, such as GIT, and related code reproducibility practices, such as documentation, is requiredExceptional communication, presentation, and interpersonal skills to effectively distill complex technical concepts for a broad range of stakeholders is necessaryA highly self-motivated individual with the ability to work independentlyPreferred Experience and Skills:Proficiency in creating effective visualizations using platforms such as seaborn, matplotlib, ggplot2Experience with high-performance or cloud computing environments (e.g., AWS) and data lake platforms (e.g., Databricks)Prior experience working in a multidisciplinary environment within the Pharmaceutical Industry, Regulatory Agencies, or Academic InstitutionsNOTICEFORINTERNALAPPLICANTSIn accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package
To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.#EligibleforERP #DATA2025Current Employees apply HERECurrent Contingent Workers apply HEREUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities
Please click here if you need an accommodation during the application or hiring process.We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S
Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA SupplementPay Transparency NondiscriminationWe are proud to be a company that embraces the value of bringing diverse, talented, and committed people together
The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively
Learn more about your rights, including under California, Colorado and other US State ActsU.S
Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S
will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely
Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States
Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.Expected US salary range:$151,900.00 - $239,200.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days
A summary of benefits is listed here.San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities
All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company
No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place
Where agency agreements are in place, introductions are position specific
Please, no phone calls or emails. Employee Status: RegularRelocation:Domestic/InternationalVISA Sponsorship:YesTravel Requirements:10%Flexible Work Arrangements:HybridShift:1st - DayValid Driving License:NoHazardous Material(s):NoRequired Skills:Business Intelligence (BI), Database Design, Data Engineering, Data Modeling, Data Science, Data Visualization, Machine Learning, Software Development, Stakeholder Relationship Management, Waterfall Project ManagementPreferred Skills:Job Posting End Date:11/22/2024*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date
Please ensure you apply to a job posting no later than the day BEFORE the job posting end date
SummaryLocation: USA - Pennsylvania - West Point; USA - California - South San Francisco (Grand Ave)Type: Full time
