Senior Scientist II, Molecular Profiling and Drug Delivery - AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

AbbVie is seeking a highly motivated, collaborative scientist with a proven track record in physicochemical characterization and application of drug delivery approaches in preclinical development of small molecule and/or biologics candidates. The primary role of this position is to serve as an MPDD project leader on discovery programs, providing preclinical formulation support for initial safety and efficacy assessments. The ideal candidate will have experience with a range of formulation techniques as well as various routes of administration. Familiarity with solid oral dosage forms including nanoparticles, amorphous systems and lipids is expected. Experience with lipid nanoparticles is a plus.

Key responsibilities include:

• Execution of studies to characterize the physicochemical properties of candidate molecules in preclinical development as it relates to crystalline or amorphous solid forms, their solubilities/rates of dissolution and their impact on formulation/excipient selection
• Design and preparation of formulations, including solutions/suspensions/emulsions, to enable preclinical acute and chronic in vivo studies
• Interpret and communicate results from characterization and formulation studies to advise the selection of molecules with properties suitable for development

Basic:

• BS (12+ yrs. experience), MS (10+ yrs. experience) or PhD (4+ yrs experience) in Pharmaceutics, Pharmaceutical Sciences, or Chemistry.

Preferred:

• Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
• Working knowledge of physiological barriers to drug absorption, including various potential transport mechanisms.
• Working knowledge of typical formulation approaches and routes of administration (i.e. IV, SC, IP, PO) across multiple species.
• Experience with analytical approaches toward physicochemical characterization of pharmaceutical dosage forms (i.e. HPLC, UPLC, MS, DSC, TGA, DVS, PXRD, dissolution)
• Experience with various milling techniques and particle size analysis
• Understanding crystalline and amorphous materials and their impact on drug development
• Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
• Excellent self-management and organizational skills.
• Demonstrated ability to work collaboratively in a cross functional team setting.

Key AbbVie Competencies:

• Builds strong relationships with peers to facilitate communication and enable higher performance.
• Learns fast, grasps the “essence” and can change the course quickly where indicated.
• Connects ideas from disparate fields, integrates data and information quickly, and takes risks to achieve the highest performance.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others and nurtures innovation

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• This position is located at 222 Jocobs Street, Cambridge, MA (Legacy Cerevel Therapeutics).
• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
• This job is eligible to participate in our short-term incentive programs. ​
• This job is eligible to participate in our long-term incentive programs​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html 

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html