Associate Director, Antibody Engineering - AlivaMab Discovery Services

AlivaMab Biologics is seeking an outstanding Associate Director of Antibody Engineering to lead our Antibody Engineering and Molecular Biology Team. This position will head a team of scientists responsible for designing, generating, and characterizing antibody-based therapeutics, including multispecifics and other advanced modalities. The Associate Director will report to the Sr. Director of Antibody Engineering and Protein Sciences and work closely with scientists and leaders in the Antibody Discovery, Protein Sciences, and Project Management teams. The position requires the candidate to lead antibody engineering through display technology, rational design and combinatorial approaches, and computational engineering. This role also requires the ability to contribute to the expansion of antibody engineering capabilities and new technologies for antibody drug discovery.

AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics, and developability, with expanding capabilities for engineering advanced modalities, including multispecifics, single-domain human VH antibodies, and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

Responsibilities

• Lead an antibody engineering and molecular biology team of scientists responsible for designing, generating, and characterizing antibody-based therapeutics, including advanced modalities such as multispecific, common light chain, single-domain human VH antibodies.
• Contribute to developing a robust phage-based immune repertoire display platform for forced common light chain and single domain human VH antibody discovery and optimization.
• Design, lead, and execute engineering campaigns to deliver cutting-edge, developable biologics formats by applying a variety of techniques including molecular biology, phage display, combinatorial, structure-guided, and computational approaches
• Lead technology development in antibody engineering and molecular biology.
• Develop and employ complex molecular biology workflows to rapidly generate constructs from various in silico and biological sources.
• Interact and collaborate with leaders and teams across antibody discovery, protein sciences, and project management on project delivery and new technology development
• Generate precise technical summaries and maintain proper documentation for partner-facing external presentations.
• Provide growth opportunities and career development support for staff. Carry out performance management/reviews for staff.

Key Skills and Requirements:

• PhD in a relevant scientific area, such as antibody or protein engineering, protein biochemistry or biotechnology, plus a minimum of 8 years of professional experience in biologics research.
• Deep understanding of diverse biologics formats, including multispecific antibodies, single-domain antibodies, ADCs, and other modalities.
• Hands-on experience with antibody phage display platforms is required.
• Experience with protein engineering to improve developability and affinity modulation is preferred.
• Understanding NGS-based repertoire analysis is highly desired.
• A background in structure-based antibody design and engineering is desired.
• Excellent communicator and highly effective in interacting with key internal and external stakeholders.
• Team player and builder, possess great coaching skills, and have great organizational skills.
• High degree of professionalism and dedication to exceptional quality and integrity.

About AlivaMab Biologics
AlivaMab Biologics sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners’ design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team’s experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.

AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

Salary range : $160,000 – 195,000

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