Associate Scientist, Platform Technology - Editas Medicine

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Position Summary

Editas is seeking a highly motivated Associate Scientist to join our Platform Technology Group. In this role, you will use various CRISPR delivery systems to execute high-throughput screens, and extract samples for NGS (DNA), RT-ddPCR (RNA) and protein (flow or Western blots/Jess automated blots) readouts to identify lead guides across our internal and external programs.  You will track screens through the LIMs and document in your ELN and be responsible for the analysis and summary of the screens to inform follow-up experiments. An ideal candidate should have a strong background in immortalized (hepatocytes) and primary cell culture (HSC, T cells) and have experience screening in these cell types using various CRISPR delivery systems, including RNPs and LNPs.

Key Responsibilities:

• As the Associate Scientist I, Platform Technology, you will be responsible for:
• Lead guide design, screening and selection of lead guide using editing and/or function assays for internal and external partner programs.  
• Analyze and summarize screening results into proper documentation (ELN, Study Reports) 
• Implementation of a high-through LNP screening workflow, including automated LNP-formulations 
• Assist with RNP complexation and perform QC for internal program use 

Requirements

The ideal candidate will possess:

• B.S. in cell biology, or related field with 5+ years of relevant experience in industry; or M.S. in cell or molecular biology with 2+ years of relevant experience in industry 
• Independently design and run screening experiments, extract gDNA, submit for sequencing, analyze, and present data 
• Experience with mammalian cell culture, including immortalized and primary cells (ex. Liver Cells and HSCs) 
• Proficient in executing and analyzing functional assays including flow cytometry and western blots 
• Experience working with different screening modalities such as guide RNAs and LNPs and knowing how to formulate both RNP and LNPs 
• Experience with data analysis software such as PRISM, Tableau, and FlowJo  
• Familiar in molecular biology analyses such as qPCR and ddPCR 
• Familiar working with lab automation including both liquid handling robots (Biomek I7s, Mantis, Echo) and plate readers (Envision) 
• Excellent communication and interpersonal skills fostering effective teamwork 

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.

Fostering Belonging. Fueling Innovation. Transforming Lives.