Senior Principal Software Engineer - Parabilis Medicines

Why join us?

Parabilis Medicines (formerly FogPharma) is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis is headquartered in Cambridge, Mass.

What's the opportunity?

We seek a highly talented and motivated Senior Principal  Software Engineer to help design, build, and support the Helicon^TM peptide drug discovery and development platform. Reporting to the Senior Director of Research Informatics, the candidate will work collaboratively with chemists, biologists, data scientists and software engineers, leveraging skills in software development to build software to enable hypothesis generation and data insights for advancing Parabilis preclinical and clinical drug programs.

You'll be part of a data science and engineering team that is a central pillar of our innovative discovery and development platform and pipelines targeting deadly diseases affecting patients and their families. Our data science and engineering team is an integrated team ranging from computational biology, bioinformatics, computational drug discovery, data and software engineering. We work at the interface of chemistry, biology, clinical and computational sciences, and are responsible for all aspects of data science and engineering.

Responsibilities:

• Establish, implement, and ensure adherence to software development best practices, coding standards, and quality assurance processes.
• Lead development of robust and reliable software solutions to ensure our success is repeatable, consistent, and scalable.
• Play a role in all the phases of software development, from requirement gathering, analysis, design, development, testing, and final release to customers.
• Collaborate with peers and leaders in other departments to align engineering efforts with company goals.
• Help make strategic decisions about what to build, buy, or partner
• Conduct regular code reviews and provide constructive feedback to improve the quality and efficiency of the developers.
• Oversee the design, development, and deployment of technology solutions from internal and external groups.
• Foster a collaborative and inclusive team culture.
• Communicating technical progress and challenges to leadership.

What you'll need to be successful:

• 10+ years of experience in software engineering.
• Deep understanding of Python, and distributed and parallel computational design
• Experience with cloud technologies (AWS, Azure) and microservices architecture is required.
• Experience with DevOps, CI/CD systems, release management, and technical documentation
• Experience with MLOps and Data Science environments
• Advanced experience working in agile methodology and productivity tools.
• Experience in life sciences is preferred.
• Proactive, detail-oriented, organized, and self-sufficient
• Strong communication skills to drive cross-functional buy-in and alignment
• Exceptional decision-making and prioritization skills
• Self-starter and ownership attitude
• Ability to work on-site and attend in-person meetings

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com