Director, Program Management at Obsidian Therapeutics

Director, Program Management

Cambridge, MA

About Us…

Obsidian Therapeutics is expanding the reach of TIL therapy.  We are pioneering engineered tumor infiltrating lymphocyte (TIL) therapies to deliver transformative outcomes for patients suffering from solid tumor malignancies. Obsidian’s programs apply our cytoDRiVE® platform technology to express regulated therapeutic proteins to enhance anti-tumor activity. We’re currently investigating our lead program OBX-115 and enrolling patients in an ongoing clinical trial in advanced or metastatic melanoma.

We’re proud of our diverse talented team and committed to cultivating an environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our research team is based in the heart of Cambridge, MA, and our Technical Development, Manufacturing & Quality team is based in our facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.

On April 3, 2024, we announced closure of a significantly oversubscribed $160.5 million Series C financing with a top-tier syndicate of life science investors led by new investor, Wellington Management. Proceeds from the financing will advance Obsidian’s lead program in its ongoing trials. We’re focused on enrolling patients and reaching key clinical and regulatory milestones, as well as manufacturing scale-up ahead of pivotal trial readiness.

Our Opportunity…

We’re looking for an experienced Program Manager to enable and ensure exceptional cross-functional planning, execution and advancement of OBX-115 and other Obsidian program(s) based on company strategy; and advance norms of transparency, critical thinking, risk mitigation, urgency, and accountability across the Program Strategy Teams (PSTs) and the operational teams that execute the work.   

This is a unique opportunity to be a contributor in a well-funded clinical company with blue chip investors, field-leading advisors, best-in-class partners, and an experienced team. You'll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.   

You Will…

Guide and develop program strategy and goals in partnership with Program Leads.  
• Develop agendas, schedule and facilitate team meetings, issue written minutes.   
Organize and manage program files and platforms for team communication, and regularly update databases and trackers.   
• Create and manage project timelines in MS Project. 
Partner closely with CMC, Clinical, Regulatory, Research, and Corporate Development to create integrated development plans that define goals, milestones, decision points, critical paths, timeline, risks, assumptions, alternative scenarios, and budgets.  
• Identify opportunities to optimize operational plans and reduce timelines and costs.  
Ensure constant communication within the cross-functional teams so that all parties are aware of program activities, decisions, progress, issues, and contingencies; and are able to respond to the implications of any changes. Document and communicate key decisions within the team and beyond as appropriate. 
• Prepare summary information on program progress including timeline updates and slide presentations.  

You Bring…

Core Qualifications 

Degree in biological sciences, (bio)chemical engineering, or related discipline with 10+ years of relevant professional experience.  
• 5+ years Program Management in drug development; cell or gene therapy experience required.  
Proven initiative, problem solving, and ability to manage matrixed projects and tasks to completion.  
• Strong scientific acumen.  
Deep understanding of GxP Operations and Regulatory requirements. 
• Expertise in MS Project, PPT, and other related applications. 

Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.