Institute Associate Scientist III -ADME/PK - MD Anderson
Houston, TX
About the Job
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
The Institute for Applied Cancer Science is seeking a highly motivated and team oriented individual to join our ADME/PK group to support our fast-paced drug discovery programs. The position requires a highly self-motivated individual, with organizational skills, and the ability to effectively present results and conclusions to co-workers and managers. A collaborative attitude is essential for this position.
The ideal candidate should be motivated for a career in the field of ADME/PK and have good knowledge of organic chemistry and analytical chemistry. Experience in LC-MS/MS is preferred but not required. The candidate will be trained to conduct in vitro ADME assays using biomatrices such as liver microsomes and/or hepatocytes and conduct bioanalysis using triple quadrupole LC-MS/MS instruments. The candidate will also be trained in metabolite identification using a high-resolution mass spectrometer.
They will have good communication skills and will regular liaise with other members of the cross-functional project team. This individual will be a key contributor in the identification and optimization of the next generation of cancer therapeutics.
KEY FUNCTIONS
1. Under minimal supervisions, perform in vitro ADME assays on drug discovery programs, such as liver microsomal and hepatocytic stability assays, plasma protein binding assays, and MDCK cell permeability assays.
2. Under minimal supervision, conduct metabolite identification of small molecule drug candidates using LC-HRMS.
3. Troubleshoot issues with assay performance and monitor assay quality.
4. Conduct quantitation analysis of small molecules in various biological matrices using LC-MS/MS.
5. Maintain and troubleshoot triple quadrupole and high-resolution mass spectrometers.
6. Participate in integrated drug discovery research project teams and interact across cross-functional groups including members of medicinal chemistry, in vitro & in vivo pharmacology, and biology teams.
7. Work closely with research teams and contribute to the optimization of ADME properties of new target molecules.
8. Employ safe lab practice.
9. Maintain research records and laboratory notes.
Working Conditions
Office environment
Physical Demands
Indicate the time required to do each of the following physical demands:
EDUCATION:
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
EXPERIENCE:
Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.
Preferred: Prior ADME experience is preferred but not required. Organic/medicinal chemists considering career changes are encouraged to apply. The ideal candidate should be motivated for a career in the field of ADME/PK and have experience in analytical chemistry. Experience in LC-MS/MS is preferred but not required.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information
#LI-Onsite
The Institute for Applied Cancer Science is seeking a highly motivated and team oriented individual to join our ADME/PK group to support our fast-paced drug discovery programs. The position requires a highly self-motivated individual, with organizational skills, and the ability to effectively present results and conclusions to co-workers and managers. A collaborative attitude is essential for this position.
The ideal candidate should be motivated for a career in the field of ADME/PK and have good knowledge of organic chemistry and analytical chemistry. Experience in LC-MS/MS is preferred but not required. The candidate will be trained to conduct in vitro ADME assays using biomatrices such as liver microsomes and/or hepatocytes and conduct bioanalysis using triple quadrupole LC-MS/MS instruments. The candidate will also be trained in metabolite identification using a high-resolution mass spectrometer.
They will have good communication skills and will regular liaise with other members of the cross-functional project team. This individual will be a key contributor in the identification and optimization of the next generation of cancer therapeutics.
KEY FUNCTIONS
1. Under minimal supervisions, perform in vitro ADME assays on drug discovery programs, such as liver microsomal and hepatocytic stability assays, plasma protein binding assays, and MDCK cell permeability assays.
2. Under minimal supervision, conduct metabolite identification of small molecule drug candidates using LC-HRMS.
3. Troubleshoot issues with assay performance and monitor assay quality.
4. Conduct quantitation analysis of small molecules in various biological matrices using LC-MS/MS.
5. Maintain and troubleshoot triple quadrupole and high-resolution mass spectrometers.
6. Participate in integrated drug discovery research project teams and interact across cross-functional groups including members of medicinal chemistry, in vitro & in vivo pharmacology, and biology teams.
7. Work closely with research teams and contribute to the optimization of ADME properties of new target molecules.
8. Employ safe lab practice.
9. Maintain research records and laboratory notes.
Working Conditions
Office environment
This position requires: | | | |
| | Working in Office Environment | ____No | __X_ Yes |
| | Working in Patient Care Unit (e.g. Nursing unit; outpatient clinic) | _X_ No | ____ Yes |
| | Exposure to human/animal blood, body fluids, or tissues | __X__No | __ _ Yes |
| | Exposure to harmful chemicals | __X__No | ___ Yes |
| | Exposure to radiation | _X_ No | ____ Yes |
Physical Demands
Indicate the time required to do each of the following physical demands:
| | Time Spent | ||||
| Never 0% | Occasionally 1-33% | Frequently 34-66% | Continuously 67-100% | ||
| Standing | | | X | | |
| Walking | | X | | | |
| Sitting | | | X | | |
| Reaching | | X | | | |
| Lifting/Carrying | |||||
| | Up to 10 lbs | | X | | |
| | 10lbs to 50 lbs | X | | | |
| | More than 50 lbs | X | | | |
| Pushing/Pulling | |||||
| | Up to 10 lbs | | X | | |
| | 10lbs to 50 lbs | X | | | |
| | More than 50 lbs | X | | | |
| Use computer/keyboard | | | | X | |
EDUCATION:
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
EXPERIENCE:
Required: Three years of relevant research experience in lab. With preferred degree, one year of required experience.
Preferred: Prior ADME experience is preferred but not required. Organic/medicinal chemists considering career changes are encouraged to apply. The ideal candidate should be motivated for a career in the field of ADME/PK and have experience in analytical chemistry. Experience in LC-MS/MS is preferred but not required.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Additional Information
- Requisition ID: 165796
- Employment Status: Full-Time
- Employee Status: Regular
- Work Week: Days
- Minimum Salary: US Dollar (USD) 76,650
- Midpoint Salary: US Dollar (USD) 95,300
- Maximum Salary : US Dollar (USD) 114,975
- FLSA: exempt and not eligible for overtime pay
- Fund Type: Soft
- Work Location: Onsite
- Pivotal Position: Yes
- Referral Bonus Available?: Yes
- Relocation Assistance Available?: Yes
- Science Jobs: Yes
#LI-Onsite
Source : MD Anderson