Life Science Research Professional 3 at Stanford University

Stanford University is seeking a Life Science Research Professional 3 to perform complex functions and activities involved in defined research projects, and independently conduct a major portion of the research project(s).

You will be working with an unparalleled leading-edge community of faculty and staff that are fundamentally changing the world of health care. You will have the opportunity to influence and drive change with your innovative ideas, the ability to make a difference and participate in human advancements. Our culture is fast-paced, energetic, and growing all of the time.

We offer a variety of benefits beyond traditional medical, dental, retirement, and savings options:

• Events and program for children, sports camps, tuition options
• World-class intellectual stimulation through learning and development classes, workshops, and onsite conferences from leading-edge speakers and faculty
• Work/life and family-friendly policies and reimbursement
• Participation in Stanford’s social responsibility and sustainable programs for a better world
• A vibrant university culture that values the uniqueness of each individual

We are seeking candidates who are progressive thinkers, see challenges as simply problems to solve, and have the spirit and energy to change the world.

About the Department of Pathology:

The Department of Pathology at Stanford School of Medicine, one of its founding departments, stands as a leader among its peers nationwide. Our preeminent faculty spans from emerging leaders to highly accomplished physicians and scientists, including a Nobel laureate and members of the National Academy. Our mission is to improve the diagnosis, treatment, and basic understanding of the human disease. This is done through discovery (research), education, and clinical care.

Comprised of extraordinary faculty and staff, our mission is to improve the ability to diagnose, treat and understand the origin and manifestation of human disease, and to care for those who have or are at risk to develop disease. We accomplish this through our clinical services (in all fields of anatomic and clinical pathology, including molecular and genomic pathology, histocompatibility testing and transfusion medicine) and research (which includes basic, translational and clinical research into the origins and manifestations of disease, including efforts to improve disease prediction and prevention as part of the goal of achieving precision medicine and health), and also by educating future leaders in pathology and related fields. Everything we do is to achieve the goals of providing the highest quality of clinical services to the patients for whom we passionately care, to advance our ability to understand, diagnose, monitor and ultimately to cure disease or to prevent or delay its occurrence, and to provide outstanding education and career development opportunities to those who share these goals.

For more information about the department visit http://pathology.stanford.edu/

Lab Overview:

The Satpathy Lab studies fundamental principles of the immune system in health, infection, and cancer (Parker et al, Cell 2020; Flynn et al, Cell 2021). The lab particularly focuses on single-cell genomic and multi-omic technologies (Yost et al, Nature Medicine 2019; Rubin et al, Cell 2019) to study immunological mechanisms of disease directly in samples isolated from patients. For more information about our multidisciplinary research laboratory, see https://satpathylab.com/

We are recruiting a Life Science Research Professional to join a new research group within the lab focused on using gene editing and high-dimensional screening in primary human immune cells to parse the biology of cancer-immune interactions and develop new immune cell-based cancer therapies. This gene editing focused group is located at the Stanford Blood Center (3373 Hillview Ave), a short bike ride from the main campus, and is led by Dr. Theo Roth, MD, PhD. The group’s work involves synthetic re-writing of human T cell genomes using non-viral gene editing (Roth et al, Nature 2018) in high throughput arrayed and pooled genetic screens (Roth et al, Cell 2020; Blaeschke et al, Cell 2023).

About the Position:

Working as part of a multidisciplinary group, the Life Science Research Professional 3 will lead the design and construction of large libraries of DNA sequences for cellular engineering experiments, isolate and culture primary human immune cells and stem cells, and large scale pooled genetic screens. Additional major responsibilities will include next-generation sequencing library production and analysis. The LRSP will assist in grant applications, reporting, and publication of laboratory findings, as well as mentorship of technicians, trainees, and students in the laboratory.

Duties include:

• Design research approaches for a major portion of research project(s), including background research, experimental design and execution, problem-solving, and writing up for publication.
• Develop new protocols; test and evaluate a variety of approaches.
• Perform complex (lab and/or field) experiments and maintain detailed records of experiments and outcomes; analyze and interpret research data resulting from original procedures and methods.
• Assist with new research proposals and applications for funding and grants.
• Lead or participate in multidisciplinary teams across different faculties or schools.
• Prepare periodic progress reports or written reports on all phases of the research project.
• Contribute substantively to the preparation of papers for publication, especially in the results section. May be a co-author on publications. Present ongoing work and findings to colleagues at academic conferences.
• Perform ongoing literature review to remain current with new procedures and related research; propose new research directions based on new advances discussed in literature.
• Work with health and safety department to ensure lab complies with regulations and all required trainings.
• Formally supervise and train new staff or students as needed, including hiring, performance management, and related duties, in addition to instruction on techniques and consultation on project work.

* - Other duties may also be assigned