Manager, R&D Accounting & Finance at Inozyme Pharma

Position Overview:

The Finance team at Inozyme Pharma is seeking an energetic, highly motivated, and experienced accounting and finance professional to fill a critical role responsible for partnering with the clinical operations and clinical manufacturing teams, performing month end closes and assisting with oversight of R&D spend.  Reporting to the Senior Manager, Accounting & Finance, the successful candidate possesses strong analytical and collaboration skills, and is comfortable respectfully challenging the status quo, always looking for opportunities for improvement.

Reporting Relationship: This position reports to the Head, Finance & Accounting

About Inozyme Pharma:

Inozyme Pharma is a pioneering clinical-stage biopharmaceutical company dedicated to developing innovative therapeutics for rare diseases that affect bone health and blood vessel function. We are experts in the PPi-Adenosine Pathway, where the ENPP1 enzyme generates inorganic pyrophosphate (PPi), which regulates mineralization, and adenosine, which controls intimal proliferation (the overgrowth of smooth muscle cells inside blood vessels). Disruptions in this pathway impact the levels of these molecules, leading to severe musculoskeletal, cardiovascular, and neurological conditions, including ENPP1 Deficiency, ABCC6 Deficiency, calciphylaxis, and ossification of the posterior longitudinal ligament (OPLL).

Our lead candidate, INZ-701, is an ENPP1 Fc fusion protein enzyme replacement therapy (ERT) designed to increase PPi and adenosine, enabling the potential treatment of multiple diseases caused by deficiencies in these molecules. It is currently in clinical development for the treatment of ENPP1 Deficiency, ABCC6 Deficiency, and calciphylaxis. By targeting the PPi-Adenosine Pathway, INZ-701 aims to correct pathological mineralization and intimal proliferation, addressing the significant morbidity and mortality in these devastating diseases.

Essential Duties and Responsibilities:

• Establish strong collaborative relationships with Clinical Operations and CMC teams to provide financial support for clinical study and manufacturing spend
• Lead and ensure the smooth execution of monthly and quarterly R&D closing processes to drive timely financial reporting
• Prepare journal entries, provide appropriate support, and resolve all reconciling items for each accounting period for clinical and CMC along with other R&D functions, as needed
• Partner with department heads and operations teams to review and conclude on monthly accruals
• Analyze and provide commentary on the balance sheet and income statement variances
• Assist with the preparation of monthly and ad-hoc reporting for senior management
• Collaborate with accounting team to support external audits and assist with the preparation of workpapers in advance of audits
• Support financial analysis and reporting for Clinical Operations and CMC including monthly budget to actuals reviews
• Support annual budgeting and quarterly reforecasting cycles
• Maintain modeling for clinical trials and manufacturing to ensure accuracy in latest estimate forecasting
• Take a lead role in special projects focused on improving the quality and efficiency of accounting processes, particularly to streamline and shorten the close process
• Manage additional projects and requests, as needed

Educational Qualifications: Bachelor’s or master’s degree in accounting or finance

Additional Qualifications:

• Experience working for an early to mid-stage biotech company preferred
• 5+ years of experience in accounting and finance
• Knowledge of clinical trials, manufacturing and related business partnership supporting an R&D organization
• Ability and willingness to meet business critical deadlines
• Ability to work collaboratively and effectively with others and a strong desire to make a positive impact
• Highly organized and detail-oriented, with strong problem-solving and communication skills, including the ability to translate financial concepts to individuals outside of Finance
• Motivated and flexible team player with the ability to wear multiple hats and prioritize tasks in a fast-paced, deadline-driven environment
• Ability to identify inefficiencies, provide suggestions, and drive positive change
• Experience working in a full-scale ERP system, and the ability to quickly learn and understand various financial accounting systems. (NetSuite, Concur)