Post Doctoral Fellow - Neurotoxicologist and Biomarker - Pfizer
Groton, CT
About the Job
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development (R&D) is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. As a post-doctoral scientist in Comparative Medicine - Drug Safety R&D (CM-DSRD) organization, you will apply cutting edge technologies to accelerate and bring the best-in-class and safe medicines to patients around the world.
What You Will Achieve
As a Post-doctoral Fellow, you will be part of Animal Models and Imaging (AMI) group within the Global Discovery, Investigative and Translational Sciences (GDITS) team. You will collaborate with multi-disciplinary and talented scientists towards development of assays and safety biomarkers to predict neurotoxicity of drug candidates prior to human clinical trials and investigate the pathogenesis of neurotoxicity by selected molecules. Your goals will be:
Establish an in vitro system using human iPSC-derived and rodent primary sensory neurons in-house to explore translatable safety biomarkers of peripheral neuropathy.
Test mechanistic hypothesis and interventions to further define the pathogenesis of neurotoxicity on human iPSC derived neurons and rodent primary sensory neurons.
Your strong foundation in cellular neurophysiology, neuropharmacology or neurotoxicology, molecular and in vitro techniques, and related principles and concepts will enable you to assess the assigned tasks and design approaches that involve direct application of your knowledge.
It is your dedication, innovative ideas, and focus that will help in making Pfizer ready to achieve new milestones and help oncology patients across the globe.
How You Will Achieve It
Driving innovation, independent thinking, problem solving, and meticulous design, execution and interpretation of experiments under minimal supervision.
Collaborate with multi-disciplinary, investigative CM-DSRD teams and scientists working on in vitro assays assessing cellular/neurotoxicity using various platforms (including MultiOmics and Biomarkers).
Work with mentors and develop and apply complex in vitro assays for exploring translatable biomarkers on human iPSC derived neurons. Refine the biomarkers and benchmark with known tool compounds.
Develop and apply complex in vitro assays for exploring translatable biomarkers using human iPSC-derived neurons.
Present the research work at various internal and external meetings and conferences and publish in relevant peer-reviewed journals.
Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and neurotoxicology expertise.
Ensure all tasks and responsibilities are carried out according to scientific, ethical and regulatory standards.
Qualifications
Must-Have
Ph.D. in neuroscience, neurotoxicology, neuropharmacology or related fields. No more than 2 years of post-degree experience
Demonstrated experience in diverse cellular, biochemical and molecular laboratory techniques with strong background in cell biology.
Possess experience using hiPSC-derived cells and neuropathy cellular or animal models.
Knowledge and hands-on experience in immunofluorescence imaging, calcium image on cell lines, iPSC-derived cells, and primary neurons.
Well organized, self-motivated, team-oriented with ability to multitask with high attention to detail.
Strong collaborative spirit and communication skills.
Successful record of scientific accomplishments as indicated by scientific publications and/or presentations. At least one first-author publication in peer-reviewed scientific journals.
Willingness to make a minimum 2-year commitment.
Nice-to-Have
Experience in rodent primary sensory neuron isolation and characterization using immunostaining or electrophysiology.
Familiar with image J, GraphPad, or other digital image analysis software.
Knowledge or experience in nerve injury or peripheral neuropathy.
OTHER JOB DETAILS
Must have work authorization in the US.
Work Location Assignment: On site
The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development
