Post Doctoral Scientist - RNA Pharmacokinetics at Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

We serve an extraordinary purpose. For more than 140 years, we have worked diligently to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges.

At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Cambridge shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

We are seeking a skilled and motivated postdoctoral candidate with strong research and communication skills to help advance a highly collaborative drug discovery and development team in the Lilly Genetic Medicine and ADME group in Cambridge, MA. Your work will contribute to a greater understanding of the clearance mechanisms and durability of RNA-based therapeutics. The successful candidate will implement their deep understanding of molecular biology to evaluate oligonucleotide pharmacokinetics at both in vitro and in vivo levels. Their ability to make data-driven decisions, learn new technologies and implement platforms will allow them to play a critical role in supporting early discovery efforts.

Job Responsibilities:

• Develop high-sensitivity PCR-based approaches of measuring oligonucleotides in different matrices.
• Establish cell culture models to study oligonucleotide pharmacokinetics & dynamics in vitro, using molecular biology and confocal imaging tools.
• Conduct sample preparation and analysis on rodent tissue and cell culture samples to inform oligonucleotide tissue residence and clearance patterns.
• Engage with RNA synthetic chemists, ADME scientists, bioanalytical chemists, protein biochemists, and in vivo pharmacologists to lead this research effort.
• Maintain external awareness and learning to benefit the organization.
• Present findings at conferences and publish in high quality peer-reviewed journals.

Basic Qualifications:

• PhD in molecular biology, pharmacology, physiology, or a closely related field.

Additional Skills/Preferences:

• Knowledge and experience in qPCR and dPCR techniques.
• Knowledge and experience in cell and tissue culture.
• Self-directed and highly motivated individual with desire to learn new techniques, while pursuing research and publication goals.
• Expertise in RNA or protein biochemistry, drug metabolism and biotransformation. 
• Expertise in molecular biology techniques for development of assays.
• Knowledge and experience in rodent tissue handling and processing.
• Experience with tissue and cellular fractionation.
• Knowledge and experience in confocal or live cell imaging.
• Understanding of pharmacokinetics or mechanistic modeling.
• Proficient in data analysis and reporting. Basic knowledge of Microsoft Office, GraphPad Prism.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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