Postdoctoral Fellow - Greenblatt/Yang Labs - Hospital for Special Surgery
New York, NY 10021
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Working with colleagues who love what they do and are deeply committed to our Mission, you too can be part of our transformation across the enterprise.
Postdoctoral Fellow
Bostrom Lab
Full-Time
Position Overview:
Postdoctoral Fellow position is available in the Arthroplasty Research Lab of Dr. Mathias Bostrom at Hospital for Special Surgery Research Institute (HSSRI), to understand how stem cell mediate bone regeneration and orchestrate a composite tissue regeneration program.
This project will be mainly supported by a newly funded NIH R01 with Dr. Matthew Greenblatt of Weill Cornell Medicine and Dr. Xu Yang of the Arthroplasty Research Lab at HSSRI as Co-PIs. We will develop key initial elements of a new approach for the regeneration of amputated limbs, by transducing a specific population of autologous skeletal stem cells to induce a blastema-like state, and then implanting them into the amputation site to initiate regeneration of the missing limb.
The candidate may also participate in other projects to invest the cellular and molecular mechanism of orthopaedic implant osseointegration, including an on-going project funded by Department of Defense, with Dr. Xu Yang as the PI.
Candidate having a recent Ph.D. degree in Developmental Biology, Cell and Molecular Biology, or Neuroscience will be desirable. Writing skill and expertise in mouse genetics, light and confocal microscopy, and gold-stand techniques of cell and molecular biology are required. The candidate is expected to have one or more high quality first author publications on cell biology or mouse models of disease or both. The candidate should be highly motivated and productive and interested in a career in research. Expertise in mouse models for wound healing and/or in working with skeletal stem/progenitor lineage cells would be a plus. The postdoctoral fellow will report directly to Dr. Xu Yang to discuss the experimental plan and research direction in the area of interest and attend the weekly lab meeting with Dr. Bostrom and Dr. Greenblatt.
Major duties and responsibilities
- Design and execute experimental procedures/protocols in research involving cell and molecular biology techniques, tissue culture, histology and immunological assay, polarizing and fluorescence microscopy, and animal model system including mouse breeding and genotyping.
- Collecting, analyzing and reporting on experimental data to the Principal Investigator on a timely manner.
- Maintain accurate and detailed records and databases of all laboratory work and experiments.
- Apply standard scientific protocols to experiments, research and improve current methods, and develop, set-up, and verify new procedures in the
- Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols for research.
- Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
- Timely compile, present and discuss relevant insights about experimental results with Principal Investigator.
- Maintain and monitor proper use of laboratory equipment.
- Troubleshoot and correct erroneous results or problems with laboratory equipment.
- Draft, write, and edit scientific papers, journal articles, abstracts and progress reports related to the work.
- Maintain an integral role in the laboratory's meetings, departmental seminars, presentations, and publications.
- Organization, and recording of research material inventory, and placing order for research reagent in a timely manner
- Completion of all trainings related to work in a timely manner, including C14, animal usage, handling hazardous material, laboratory safety.
- Participate in establishing job requirements and goals; perform duties at the desired level of competency.
Qualifications:
Minimum Job Requirements
- Education/Training: PhD or medical degree
- Experience: 2+ years of experience in basic science research