Postdoctoral Fellow, Human Genetics - Pfizer
Cambridge, MA
About the Job
What You Will Achieve
This is an exciting opportunity to join theInternal Medicine Research Unit (IMRU). The strategic focus of the IMRU at Pfizer is to identify novel therapies for preventing or treating chronic cardiovascular, renal, and metabolic diseases. Our goal is to build a world-class research team of dedicated scientists committed to developing a deep mechanistic understanding of the pathways underlying disease pathogenesis.
We are seeking a Postdoctoral Fellow to join the IMRU Integrative Biology team to investigate integrative approaches that would enhance our application of human genetics and single-cell epigenomics to drug discovery. The ideal candidate must be able to independently drive their research project forward and effectively communicate their findings with scientific partners representing diverse disciplines. Knowledge and experience in either human genetics or single-cell analysis is essential, and experience researching common cardiovascular, renal, or metabolic diseases is preferred. The candidate will be expected to present their findings at scientific meetings and publish their research in a peer-reviewed journal.
How You Will Achieve It
Successful candidates will be expected to:
- Design and execute computational analyses to understand the biology underlying disease risk and mechanisms of GWAS loci through integration of genetic and single-cell genomics datasets
- Work closely with colleagues from other disciplines within Pfizer including experts in biology or machine learning
- Presentresearch findings toPfizer colleagues andthe scientific community through publications in peer-reviewed journals andtalks and postersat both internal and external scientific meetings.
Qualifications
Must-Have
- PhD in Computational Biology, Bioinformatics, Human Genetics, or related field with directly relevant experience
- Proven experience with applying standard tools and pipelines for analyzing genetics (GWAS meta-analysis, fine-mapping, colocalization, LD score regression) or large-scale single-cell (Scanpy, snapATAC2, Seurat, Signac) datasets
- Demonstrated proficiency with Python or R and experience working in a Linux/Unix high-performance computing environment
- Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal
- Demonstrated ability to effectively communicate complex genetics and computational biology results to both technical and non-technical audiences
- Willingness to make a minimum 2-year commitment
- No more than 2 years of post-degree experience.
Nice-to-Have
- Experience researching mechanisms of cardiovascular, renal, or metabolic diseases
- Experience applying sequence-based machine learning models to derive insights from genetics or single-cell datasets
- Experience integrating genetics with multi-modal (epigenomics, transcriptomics, proteomics, and metabolomics) datasets
PHYSICAL/MENTAL REQUIREMENTS
Ability to use standard and non-standard statistical and computational software; ability to perform complex data analysis
OTHER JOB DETAILS
Must have work authorization in the US.
Work Location Assignment: Flexible. Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes business sense to do so.
The annual base salary for this position ranges from $60,900.00 to $101,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development