Postdoctoral Fellow - Smith Lab - Seattle Children's

The SEPS lab ( http://faculty.washington.edu/seps ) at the Center for Integrative Brain Research, Seattle Children's Research Institute and the University of Washington invites applications for an R01-funded postdoctoral position focusing on CAR T cell signaling. Work in the SEPS lab focuses on signal transduction through protein-protein interaction networks, and employs a unique technology called Quantitative Multiplex co-Immunoprecipitation or QMI. Using QMI and molecular genetic techniques, the successful applicant will lead a project examining how specific protein interactions engaged by the CAR contribute to CAR T cell efficacy, and how patient-to-patient variability in protein levels may contribute to detrimental side effects. The successful candidate will work closely with a technician and graduate/undergraduate students to plan and supervise several parallel lines of investigation, using primary human T cells or banked patient material from completed trials. The candidate will be expected to independently move projects forward, write papers, and apply for F32 or equivalent grants. The ideal candidate will have the ability to perform precise wetlab work and complex bioinformatics analyses using MatLab and R programming. Prior experience in immunology, molecular biology, and/or CAR T cell therapy is a plus. Creative, big-picture thinking and dedication academic research are essential. The selected candidate will join the vibrant research community at CIBR, located on the newly renovated 8th floor of the Jack MacDonald building in downtown Seattle. A modern, open lab space, a collegial atmosphere, on-site gym and rooftop garden, and top-of-the-line equipment, office space and meeting rooms make this an ideal training environment. Emailed inquiries to seps@uw.edu are always welcomed. **Required Education/Experience:** - Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program. - Experience using basic research techniques of specialty area. **Preferred:** - Previous experience conducting research in the pediatric arena. - Experience in protocol and manuscript development and in grant writing. **Compensation Range** $65,478.00 - $98,571.00 per year **Salary Information** This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided. **Disclaimer for Out of State Applicants** This compensation range is specific to Seattle, positions located outside of Seattle may be compensated differently depending on various factors **.** **Benefits Information** Seattle Children's offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits . **About Us** **Hope. Care. Cure. These three simple words capture what we do at Seattle Children's - to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE** Our founding promise to the community is as valid today as it was over a century ago: we will care for all children in our region, regardless of the families' ability to pay. Together, we deliver superior patient care, advance new discoveries and treatments through pediatric research, and serve as the pediatric and adolescent, academic medical center for Washington, Alaska, Montana and Idaho - the largest region of any children's hospital in the country. In 2022, U.S. News & World Report once again ranked Seattle Children's among the nation's best children's hospitals - for the 30th year in a row. For more than a decade, Seattle Children's has been nationally ranked in all 10 specialty areas evaluated by U.S. News & World Report. We are honored to be the top-ranked pediatric hospital in Washington and the Pacific Northwest. As a Magnet designated institution, and classified among America's best large employers by Forbes, we recognize the importance of hiring and developing great talent to provide best-in-class care to the patients and families we serve. Our organizational DNA takes form in our core values: Compassion, Excellence, Integrity, Collaboration, Equity and Innovation. Whether it's delivering frontline care to our patients in a kind and caring manner, practicing the highest standards of quality and safety, or being relentlessly curious as we work towards eradicating childhood diseases, these values are the fabric of our culture and community. The future starts here. **Our Commitment to Diversity** Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics. The people who work at Seattle Children's are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels. Seattle Children's is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.