Principal Chemist - Protein Optimization at Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record for delivering novel biotherapeutic medicines to advance into clinical research in key areas of unmet medical need including diabetes, oncology, immunology, neuroscience, and others. Our diverse team is dedicated to making a significant impact by developing therapies that transform lives.

Position Overview: We are seeking a highly motivated and creative research associate with a background in protein chemistry to join the Lead Optimization Team within the BioTDR organization, based in Indianapolis. Our team is responsible for generating, characterizing, and optimizing biotherapeutics from lead generation to lead optimization and preclinical development. This role offers an exceptional opportunity to turn innovative ideas into clinical candidates.

Are you up for the challenge? Apply today and join the Lilly family!

Responsibilities

• Purifying proteins and antibodies and generation of protein/antibody conjugates followed by characterization using a variety of biochemical and biophysical techniques to identify and address issues pertaining to the physiochemical properties of protein reagents and/or potential biotherapeutics.
• Generation of protein/antibody conjugates using various conjugation methods.
• Analytical characterization of purified protein/antibodies/conjugates.
• Characterize protein structure, stability, and solution properties using various biochemical and biophysical approaches.
• Characterizing protein: protein interactions.
• Working in multifunctional teams and coordinating and presenting experimental data/results at team meetings.

Basic Requirements

• BS with 5 years of experience or MS degree in biochemistry, protein chemistry or related field and 3 years of experience in the pharmaceutical industry.

Additional Preferences

• Hands-on experience in protein purification and characterization of proteins in academic or industrial settings.
• Experience with biophysical characterization such as Biacore/SPR analysis, light scattering techniques, ITC and protein stability/thermodynamic analysis along with experience with AKTA purification and HPLC systems and methodologies are highly desirable.
• Strong core proficiency in protein biochemistry, knowledge of protein structure-function relationship, and experience in biochemical analyses are required.
• Experience with protein engineering; demonstrated ability to work in a cross-functional team environment, industry experiences including internship preferred.
• Capable of independently designing experiments, generating data, interpreting results, and documenting work.
• Effective oral and written communication skills, self-management, task planning and organization skills.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

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