Principal Scientist, Cell Therapy Molecular Design - Johnson and Johnson

Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, Cell Therapy Molecular Design located in Spring House, PA.

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/ .

For more than 130 years, diversity, equity & inclusion has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world's most pressing healthcare challenges. We know that the success of our business - and our ability to deliver meaningful solutions - depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued, and our people can reach their potential. At Johnson & Johnson, we all belong.

The Principal Scientist, Cell Therapy Molecular Design position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. This role will specifically focus on the design and generation of high-quality plasmids to support the use of engineered lentiviral vectors (LVV) for gene delivery to T cells in cancer therapies. We seek a highly motivated researcher with a solid background in molecular cloning and gene regulation to lead our high-throughput plasmid design initiatives and drive innovative discovery programs. If you have industry experience in molecular and vector engineering, we invite you to join us in our mission to build the next generation of Cell & Gene Therapies.

Primary responsibilities:

• Oversee plasmid generation to deliver high-quality vectors supporting multiple cell therapy programs in a timely manner
• Advance lentiviral expression cassette systems to incorporate complex engineering features aimed at enhancing therapeutic efficacy and safety
• Grow the efficiency and scale of plasmid generation capabilities by establishing high-throughput and automated processes
• Establish relationships with external vendors to support molecular biology needs
• Collaborate with cross-functional teams including Discovery, CMC, and Regulatory groups to ensure alignment of Molecular Design with overarching therapeutic strategy
• Execute research timelines to meet program and corporate objectives and deliver quality data
• Contribute to a collaborative, creative, and rigorous culture of scientific discovery

• Ph.D. in Molecular Biology, Gene Therapy, Cell Biology, or related field with 2 years of experience in the biotech/pharmaceutical industry; OR BS or MS with 6-8 years of related experience is required.
• Deep expertise in molecular biology, including plasmid cloning, scale-up, sequencing, and QC, is required
• Expertise engineering gene regulation systems for mammalian cells is required
• Experience managing people is required and experience managing small teams responsible for supporting multiple project teams is preferred
• Strong critical, scientific, and strategic thinking skills are required
• Strong organizational skills, with the ability to manage multiple projects in parallel and meet timelines, are required
• Demonstrated ability to work collaboratively in cross-functional teams is required
• Experience working with high-throughput automation is preferred
• This role is based in Spring House, PA

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.