Principal Scientist, Early Translational Computational Science for Immunology, Cardiovascular and Neurology - Bristol Myers Squibb
Cambridge, MA
About the Job
Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company." We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We seek a creative and passionate computational scientist with a background in addressing translational questions to join the Immunology, Cardiovascular and Neurology (ICN) Early Translational team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development. With rapidly advancing technology, approaches utilizing in-depth analysis of multiomics and clinical datasets have now advanced such that their application to drug development can help transform and enable the next wave of breakthrough therapies that can reach patients faster through innovative clinical trial designs. In this role, you will implement rigorous data analysis practices and align resources based on scientific priorities to lead analyzes of high-dimensional readouts from longitudinal patient cohorts. Your analyses will identify biomarkers predictive of patient outcomes and response to therapy and inform drug development and safety pipeline. As such, in this highly collaborative role, your work will directly inform discovery, biomarker, diagnostic and clinical development.
We are seeking a highly motivated bioinformatician with preclinical or clinical experience to join our Early Translational ICN team. The successful candidate will help advance Bristol Myers Squibb's ICN clinical programs through the strategic application of cutting-edge bioinformatics approaches.
Responsibilities
Analyze various -omic-scale biomarker data generated from human subjects in clinical trials and other observational cohorts, including RNA-Seq, Exome, and Whole Genome Sequencing, high throughput proteomics, and multiplex flow cytometry to validate pharmacodynamics effects, confirm the mechanism of action, and enable patient enrichment strategies.
Conduct analysis independently to integrate and mine large-scale external datasets to further our understanding of diseases in Immunology and Neurology.
Work both independently and collaboratively to extract insights, generate hypotheses and guide drug development decisions in our Early Clinical, Development and Translational teams and help inform our development pipeline.
Basic Qualifications:
+ Bachelor's Degree 8+ years of academic / industry experience
+ Or Master's Degree 6+ years of academic / industry experience
+ Or PhD 4+ years of academic / industry experience
Preferred Qualifications
+ Ph.D. in bioinformatics, molecular biology, genetics, engineering, statistics, or a similar discipline.
+ Four (4) or more years relevant experience in preclinical or clinical research.
+ Proficiency using R required and 1+ additional programming language preferred.
+ Strong experience in statistical modeling and/or machine learning approaches, such as mixed-effects models, predictive modeling, etc. to represent biological concepts.
+ Experience with clinical database (SDTM/ADaM) and biomarker statistical analysis is a plus.
+ Individual contributor role requiring strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation.
+ Prior experience in immunology or neurology is a plus.
+ Strong problem-solving and collaboration skills, rigorous and creative thinking
+ Ability to communicate effectively with biologists, clinicians and other computational scientists.
The starting compensation for this job is a range from $ 119,000 - 149,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.
Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Company: Bristol-Myers Squibb
Req Number: R1586763
Updated: 2024-11-06 04:24:33.306 UTC
Location: Princeton-NJ
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company." We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We seek a creative and passionate computational scientist with a background in addressing translational questions to join the Immunology, Cardiovascular and Neurology (ICN) Early Translational team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development. With rapidly advancing technology, approaches utilizing in-depth analysis of multiomics and clinical datasets have now advanced such that their application to drug development can help transform and enable the next wave of breakthrough therapies that can reach patients faster through innovative clinical trial designs. In this role, you will implement rigorous data analysis practices and align resources based on scientific priorities to lead analyzes of high-dimensional readouts from longitudinal patient cohorts. Your analyses will identify biomarkers predictive of patient outcomes and response to therapy and inform drug development and safety pipeline. As such, in this highly collaborative role, your work will directly inform discovery, biomarker, diagnostic and clinical development.
We are seeking a highly motivated bioinformatician with preclinical or clinical experience to join our Early Translational ICN team. The successful candidate will help advance Bristol Myers Squibb's ICN clinical programs through the strategic application of cutting-edge bioinformatics approaches.
Responsibilities
Analyze various -omic-scale biomarker data generated from human subjects in clinical trials and other observational cohorts, including RNA-Seq, Exome, and Whole Genome Sequencing, high throughput proteomics, and multiplex flow cytometry to validate pharmacodynamics effects, confirm the mechanism of action, and enable patient enrichment strategies.
Conduct analysis independently to integrate and mine large-scale external datasets to further our understanding of diseases in Immunology and Neurology.
Work both independently and collaboratively to extract insights, generate hypotheses and guide drug development decisions in our Early Clinical, Development and Translational teams and help inform our development pipeline.
Basic Qualifications:
+ Bachelor's Degree 8+ years of academic / industry experience
+ Or Master's Degree 6+ years of academic / industry experience
+ Or PhD 4+ years of academic / industry experience
Preferred Qualifications
+ Ph.D. in bioinformatics, molecular biology, genetics, engineering, statistics, or a similar discipline.
+ Four (4) or more years relevant experience in preclinical or clinical research.
+ Proficiency using R required and 1+ additional programming language preferred.
+ Strong experience in statistical modeling and/or machine learning approaches, such as mixed-effects models, predictive modeling, etc. to represent biological concepts.
+ Experience with clinical database (SDTM/ADaM) and biomarker statistical analysis is a plus.
+ Individual contributor role requiring strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation.
+ Prior experience in immunology or neurology is a plus.
+ Strong problem-solving and collaboration skills, rigorous and creative thinking
+ Ability to communicate effectively with biologists, clinicians and other computational scientists.
The starting compensation for this job is a range from $ 119,000 - 149,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.
Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Company: Bristol-Myers Squibb
Req Number: R1586763
Updated: 2024-11-06 04:24:33.306 UTC
Location: Princeton-NJ
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Source : Bristol Myers Squibb
