Principal Scientist, Protein Production & Process Development - Repertoire Immune Medicines

Company Overview
Repertoire Immune Medicines is a biotechnology company working to unlock and direct the remarkable power of the human immune system to treat cancer, autoimmune disease and infectious disease. The company was founded by Flagship Pioneering on the belief that understanding the repertoire of T cell receptor (TCR)-antigen immune synapses that maintain health and drive disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODE^TM platform, which allows in-depth characterization of TCR-antigen pairs, and the ability to deploy this information in the form of novel targeted immune medicines to fundamentally reprogram the immune system to kill tumors or induce immune homeostasis.

From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire’s team is creating a new pipeline of therapeutic immune medicines enabled from its DECODE discovery platform.  Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with autoimmune diseases such as type 1 diabetes and multiple sclerosis, creating programmable tolerizing mRNA vaccines to restore immune homeostasis in these indications. In oncology, Repertoire’s decoding of tumor-infiltrating lymphocytes and the antigens they target is enabling development of TCR bispecific therapies and mRNA cancer vaccines to treat solid tumors. 

Role Overview
We are seeking an experienced Protein Production and Process Development leader with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research associates and scientists focused on production of lead TCR bispecific molecules and optimization of processes.  The selected candidate and his/her/their team will work in a highly dynamic and cross-functional environment to facilitate seamless technology transfer to an external contract development and manufacturing organization (CDMO).  The incumbent will also enable Repertoire’s proprietary platform technologies with high quality pMHC products produced by microbial or mammalian systems.  The incumbent will interface with internal preclinical Immunology, Protein Modality, and DECODE platform teams, as well as the internal CMC Leader, to provide protein reagents and protein leads, including data packages supporting Development Candidate nomination.

Key Responsibilities

Develop and optimize upstream and downstream processes to generate lead and Development Candidate TCR bispecific and to enable seamless technology transfer to contract manufacturing organizations.
Provide data packages, expertise, and guidance to TCR bispecific candidate nomination decision.

Transfer analytical methods to external CROs/CDMOs and provide additional training, troubleshooting, or technical support, as necessary.

Manage technology development and production of novel pMHC reagents to enable target identification, target validation and TCR affinity maturation for both oncology and/or autoimmune indications.
Drive team engagement, ownership, and agility to deliver ambitious results.
Author and review technical documents and reports for inclusion in CMC sections of regulatory filings.

Recruitment & Staffing Agencies:Repertoire Immune Medicines (“Repertoire”) does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Repertoire or its employees is strictly prohibited unless contacted directly by Repertoire’s internal Human Resources team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Repertoire, and Repertoire will not owe any referral or other fees with respect thereto.