Research Associate, Antisense Oligonucleotide (CONTRACT) at Entrada Therapeutics

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of oligonucleotides. You will be supporting efforts for antisense oligonucleotides, small interfering ribonucleic acids and gene editing platforms. You should be ready to support our team of drug discovery scientists as we design, prepare and characterize oligonucleotide constructs and carry out analytical assays for functional validation both in vitro and in vivo.

The Opportunity

In this role, the Research Associate will have the opportunity to be involved in a lot of different aspects of our oligonucleotide work; for example, processing and analyzing samples from in vitro and in vivo studies will be one of your areas of work. They will be expected to work through techniques like RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, and Western Blot. You’ll also have the opportunity to maintain and culture cell lines for in vitro studies, as well as developing and executing cell-based assays for validating biological activity of oligonucleotide therapeutics. Lastly, the Research Associate will have the opportunity to prepare SOPs and other reports and publications.

Responsibilities

•    Maintain and culture primary and secondary cell lines for in vitro studies.
•    Develop and execute cell-based assays for validating biological activity of oligonucleotide therapeutics.
•    Use techniques like RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, and Western Blot to process and analyze samples from in vitro and in vivo studies. 
•    Produce high quality data that will contribute to new therapeutic development.
•    Contribute to reports and presentations. During internal and external meetings, you should be ready to interpret and present research data and findings. 

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BS/MS in molecular biology, pharmacology, biochemistry or similar field. At least 2+ years’ experience in a lab or industry experience.
• Hands-on biochemistry experience with techniques like RT-PCR, qPCR, ELISA, fluorescence microscopy, cell culture and western blotting and other protein assays.
• Hands-on experience with oligonucleotides is a plus.
• To be effective on our team, we need you to bring excellent working knowledge and familiarity with graphic software and Microsoft Office.
• You should be collaborative and a strong communicator and can multi-task effectively.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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