RESEARCH SCIENTIST / ENGINEER 2, Histology and Imaging Core (HIC) - University of Washington

Req #: 239960 Department: SCHOOL OF MEDICINE: COMPARATIVE MEDICINE Posting Date: 11/05/2024 Closing Info: Closes On 11/19/2024 Salary: $4,649 - $9,465 per month Shift: First Shift Notes: As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here. (https://hr.uw.edu/wp-content/uploads/sites/3/2018/02/benefits-professional-staff-librarians-academic-staff-20230119\_a11y.pdf) As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem-solving skills and dedication to build stronger minds and a healthier world. UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. The Department of Comparative Medicine (DCM) is one of 12 basic science departments in the School of Medicine. DCM is the central laboratory animal medicine resource at the University of Washington, supporting over 114,000 assignable square feet of animal facilities with an average daily census in excess of 100,000 animals across multiple species (e.g., rodents, rabbits, swine, and zebrafish). The department employs over 175 individuals who provide a comprehensive range of animal husbandry, veterinary, and laboratory services across numerous vivaria. The UW animal care program is accredited by AAALAC International and provides services to over 400 principal investigators. DCM faculty members, post-doctoral fellows, and residents conduct basic and clinical research on a wide range of subjects including, but not limited to, comparative aspects of infectious disease, aging, cancer biology and genetics. We have an outstanding opportunity for a **Research Scientist / Engineer 2** to provide research support for and operational oversight of a Shared Research Resource, The Histology and Imaging Core (HIC) in the Department of Comparative Medicine, School of Medicine, University of Washington. This resource consistently offers low-cost and efficient pre-analytic processing of research tissues for immunohistochemistry (IHC), in-situ hybridization (ISH), imaging, and quantitative assessment of IHC and ISH studies. The Histology and Imaging core also provides analysis of tissues processed in the core, including whole slide quantitative image analysis using Visiopharm analysis software. Histology and Imaging Core (HIC) provide researchers fee-for-service access to expertise and state of the art instrumentation across a broad range of services including; routine histology, immunohistochemistry, microscopy, digital imaging and quantitative digital pathology, cell based multiplex assays and comparative pathology consultation. This core is open to all investigators, including UW and their affiliates, commercial and not-for-profit biotechnology companies, and other academic institutions. Position Summary This position performs advanced immunohistochemistry and quantitative image analysis, troubleshoots and maintain cutting-edge laboratory equipment, and ensures quality control. This position drives high-quality data collection, analysis, and reporting. **RESPONSIBLITIES** Histology and Imaging Core (HIC) Evaluate Research Objectives (10%): - Assess specific research questions and determine the most relevant methodologies and techniques to address these questions effectively. o Identify key variables and metrics to be investigated, ensuring they align with the study's overall goals. o Develop a feasibility assessment for each research question, considering factors like available technology, sample size, and time constraints. o Compile a list of potential methodologies, evaluate and propose their applicability to the specific research questions based on factors such as resolution, specificity, and cost-effectiveness. Select Procedures and Techniques (10%): - Choose appropriate manual and automated brightfield and fluorescence immunohistochemistry (IHC) techniques based on the research objectives. - Select quantitative image analysis methods and stereology software tools that provide the necessary precision and accuracy. Apply Procedures and Techniques (30%): - Perform IHC, ensuring consistent application of techniques to maintain data integrity. - Conduct quantitative image analysis and stereology using specialized software to extract meaningful data. - Operate and maintain advanced imaging equipment for accurate data acquisition and analysis. Quality Control and Troubleshooting (20%): - Implement quality control measures to ensure the reliability of results from histological and imaging procedures. - Analyze instrument malfunctions, apply corrective actions, and monitor performance to prevent recurrence. Protocol Development and Training (10%): - Develop and write detailed protocols for histology and imaging procedures. - Train laboratory personnel and users on proper use of equipment and techniques, ensuring adherence to standardized procedures. Data Management and Reporting (10%): - Use VADDS and Wordpress lab information database software for accurate case accessioning, tracking, and billing. - Maintain detailed and up-to-date laboratory notebooks documenting all procedures and findings. Administration (10%): Schedule and coordinate multiple incoming shipments to the laboratory: - Perform quality assurance on incoming samples and communicate with various stakeholders. Track orders through the histology workflow and perform billing. Perform other duties as needed. **Requirements include:** - Bachelor's degree in a pathology / histology / immunohistochemistry / image analysis or related field - Two years of direct, hands-on experience with immunohistochemistry or microscopes, slide scanning, or related imaging. Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration. **Desired:** - Work with rodent models in research; good communication skills, organization, time management and independent work ethic; background in scientific field/biology Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These may include Work Authorization, **Cover Letter** and/or others. Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. **Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.** University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sexual orientation, gender identity, sex, age, protected veteran or disabled status, or genetic information.