Scientist, Bioinformatics at Avidity Biosciences

Job Title:

Scientist, Bioinformatics

Location:

San Diego, CA / Hybrid

Position type:

FLSA:

Full time

Exempt

Department:

Finance ID:

Development Sciences

8100-2023-1-P

Strive to Bring a Profound Difference to our Patients

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and Twitter.

The Opportunity

We are seeking a highly motivated bioinformatics scientist to join our group who can contribute to and help drive the expansion of our AOC platform. A successful candidate is expected to be a strong team player who will work collaboratively with cross-functional teams in both Research and Development programs to design, analyze, and interpret genomics and other multi-omics experiments. This individual should enjoy scientific discovery and collaboration in a fast-paced, interdisciplinary environment.

What You Will Contribute

• Support pre-clinical and clinical drug discovery activities, including siRNA library design, off-target analysis, disease model characterization, and biomarker development
• Collaborate with project teams to design genomic experiments, develop analysis approaches, and independently execute bioinformatics analyses
• Identify relevant internal and external data and knowledge resources and perform integrated data analyses
• Document hypotheses, experimental design, analysis methods, and results in a meticulous manner
• Communicate and collaborate with cross-functional teams; organize and present results concisely at regular team and cross-functional project meetings

What We Seek:

• PhD in Bioinformatics, Computational Biology, Statistics, Biological Sciences, Genetics, Genomics, or Computer Science, with 0-3 years of pharmaceutical industry experience or MS/BS degree with 10+ years of pharmaceutical industry experience.
• Expertise in analyzing data from microarray, NGS, proteomics, and metabolomics
• Expertise in R and/or Python, Linux, HPC, cloud computing (e.g., AWS), and version control (e.g., Github)  
• Knowledge of and experience with current bioinformatics trends, public genomic tools, databases, and utilities
• Knowledge of text mining and data mining
• Experience with open source and commercial pathway and network analysis tools
• Sound knowledge of theoretical and applied statistics
• Demonstrated ability to communicate with cross-functional teams, including Chemistry, Biology, Pharmacology, etc. A strong ability to understand and communicate with wet-lab scientists is highly desirable.
• Excellent presentation and written/verbal communication skills
• Bioinformatics expertise in translational development and RNA therapeutics (e.g., siRNA library design) is highly desirable
• Experience in muscle biology is a plus

• The base salary range for this role is $120,700 - $136,400. The final compensation will be commensurate with relevant experience, skillset, internal equity, and market factors.
• Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, RSUs, and a 401(k) with an employer match. In addition, the comprehensive wellness program includes medical, dental, vision, and LTD coverage and four weeks of time off.
• A commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.

#LI-DNI

Avidity Biosciences

10578 Science Center Dr. Suite 125

San Diego, CA

92121

O: 858-401-7900

F: 858-401-7901