Scientist--Discovery Oncology, non PhD - Pfizer
La Jolla, CA
About the Job
ROLE SUMMARY
You will translate basic discoveries in cancer biology into novel therapeutics. You will utilize cutting-edge chemical and biological tools to support our pre-clinical drug discovery programs. You will design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human cancers. You will act as a technical and scientific expert in the lab, working independently and collaboratively with team members to design, execute, analyze, interpret, and refine experiments. Experiments will cover areas include in vitro pharmacology, biomarker assay development, cell function assays, functional genomics, and mechanism of action studies.
ROLE RESPONSIBILITIES
Independently and collaboratively design and execute various cellular and molecular biology experiments to validate genetic or small molecule perturbations of targets and downstream pathways. This includes cell culture, western blot, qPCR, ELISA, MSD, immunoprecipitation, gene expression analysis, functional genomics, luminescence-based assays, imaging platforms, and flow cytometry
Conduct experiments to test the functional consequences of genetic (CRISPR-based gene editing technologies and RNA interference) and chemical perturbations in cancer cell models, advancing mechanism of action studies
Develop cellular tools to advance drug discovery projects and lead compound selection
Design and conduct well controlled high-quality scientific experiments to test biological hypotheses
Assist with the evaluation of new approaches and technologies within the group
Stay current with relevant technologies including those relating to molecular biology, cell biology, functional genomics and biochemistry; take a proactive role in personal growth and scientific development
Collaborate closely with team members within Tumor Biology and Oncology Project Teams, and present research results to team members
Maintain electronic lab notebook in compliance with company policies
Comply with all safety training and good laboratory practices
BASIC QUALIFICATIONS
Bachelor’s degree in Molecular Biology, Cell Biology, Biochemistry, Genetics/Genomics or related or related discipline with 6+ years laboratory experience in an industrial or academic setting OR
Relevant Master’s degree with 4+ years laboratory experience in an industrial or academic setting
Experience in cancer research
Strong written and verbal communication skills
PREFERRED QUALIFICATIONS
Experience in a range of molecular biology methods including cloning, vector construction, PCR, DNA and RNA isolation, qPCR, and library construction
Experience with a variety of cell biology techniques including cell culture, engineering and generation of stable cell lines, lentiviralproduction, gene expression analysis, protein expression analysis, and cell-based assays, phenotypic characterization, biomarker assays, luminescence-based assays, reporter assays, imaging assays, and flow cytometry
Experience with CRISPR-based approaches for gene knockout, gene editing, or RNA interference technologies for genetic perturbation
Track record of successful contributions to research projects, preferably in oncology research
Experience in transcriptional regulation or epigenetics
Experience in bioinformatic or genomic data analysis
Experience effectively interacting and collaborating with other scientists, both within the group and across other teams
Relocation support available
Work Location Assignment: On Premise
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development