Scientist I - AbbVie
Irvine, CA
About the Job
We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio
For more information about AbbVie, please visit us at www.abbvie.com
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Job Description The Bioanalytical group in the Department of Local Delivery and Translational Sciences is seeking a Scientist I to develop and optimize new ligand binding bioanalytical methods and perform sample analysis to generate reliable and reproducible pharmacokinetic (PK), biomarker and biodistribution data in a timely manner under the direction of a more senior scientific leader
The ideal candidate should have experience demonstrating an understanding of quantitative bioanalytical assays and related technologies
Furthermore, the ideal candidate should demonstrate the capability to read and adapt scientific literature to accomplish assignments and demonstrate broad and versatile PK and biomarker method development expertise or a closely related discipline
Responsibilities: + Independently develop and qualify PK and biomarker assays for various modalities in biological matrices, and document experimental procedures and results
+ Contribute to developing and qualifying analytical methods to characterize the biodistribution of novel gene therapy (GT) candidates using analytical methods such as tissue homogenization, digital PCR and ligand binding assays to measure levels of viral vector DNA, RNA and transgene product in biological samples
+ Perform non-GLP sample analysis for non-clinical toxicology and PK studies
+ Use statistical tools to analyze and interpret data to design follow-up experiments needed to complete assay development
+ Write and review assay development protocols, assay qualification reports, and bioanalytical reports as needed
+ Present results to management and at cross-functional meetings
+ Collaborate effectively within the group and with other departments to advance AbbVie’s large molecule programs
+ The position requires working with select agents and/or in areas that require select agents and toxins access
Candidate should understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, drug product and select agent, GxP compliance
+ Maintain laboratory equipment and optimize laboratory operations for efficient use of time and laboratory supplies and reagents, when appropriate
+ Assume additional responsibilities to support safety and organization of the lab
Qualifications Qualifications: + Bachelor’s Degree with 5 years’ experience or Master’s degree with 2 years’ experience in Biological Science, Biochemistry or similar field required
+ Candidate should be proactive, inquisitive and a self-starter who is eager to learn and thrive in fast paced environment
+ Ability to work with and in areas requiring select agents and Toxins access (i.e
Biosafety level 2)
+ Hands-on laboratory experience in support of biologics drug development and within a matrixed team environment is preferred
+ Prior experience in PK, biomarker analytical method development, molecular biology, AAV and CRISPR Gene Therapy is highly preferred
+ Compliance with AbbVie’s internal and applicable regulatory requirements involving ethics, environmental health and safety, financial, human resources, and general business policies required
Competencies: + Excellent written and oral communication skills to effectively communicate complex research findings and recommendations
+ Ability for critical thinking and strong analytical skills to evaluate complex information for the identification of key scientific findings related to projects
+ Ability to prioritize and manage multiple projects and activities while meeting tight deadlines
+ Maintains excellent working relationships with colleagues and collaborators
+ Independent, innovative, and creative thinker
+ Committed to the values of integrity, accountability, transparency, scientific rigor and drive
Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: + The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position
Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range
This range may be modified in the future. + We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. + This job is eligible to participate in our short-term incentive programs
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable
The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion
It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html
