Scientist II - in vitro ADME/Transporter Sciences - AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

The Quantitative, Translational, and ADME Sciences (QTAS) department in AbbVie Bay Area (ABA), CA is seeking a highly motivated transporter scientist to join the In Vitro ADME Science (IVAS) group. The QTAS department supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk, drug-drug interactions (DDI) and in vitro to in vivo extrapolations towards the development of clinical candidates. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, clinical pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. In this role, the candidate will be responsible for generating in vitro transporter related data and supporting early discovery to late-stage pipeline. The candidate will also could experience the rich culture of our organization. In addition, this role will also enable participation in scientific innovation projects in the field of drug transporters.

Core Job Responsibilities:

· Conducting in vitro transporter experiments using a wide range of in vitro systems such as recombinant transporter and primary cell lines to support pipeline projects in a timely manner

· Cell culture, storage (maintain cell repository-recombinant and primary) and work closely with team members

· Conducting primary hepatocytes-based in vitro uptake experiments

· Conducting HT-screening for potential inhibition of uptake transporters

· Analyzing experimental data and maintaining accurate, and comprehensible study documentations in real time

· Taking part in scientific development goals to improve data quality, capacity, and introducing new tools and techniques

A master’s or bachelor’s degree in relevant field (pharmacy, pharmacology, pharmaceutical sciences, biological chemistry or equivalent in drug metabolism or related discipline) with relevant industry experience in drug discovery/ development (+5 years with MS; +7 years with B.S)

· Excellent skills in handling and understanding of recombinant and primary cell lines (culture, seeding, storage) is critical

· Working experience in in-vitro drug transporters, metabolism, and drug-drug interactions investigations

· Working experience with LC-MS/MS based bioanalysis of in vitro experimental samples

· Proficiency in data analysis, maintaining electronic notebook, generating accurate reports.

· Strong understanding of ADME/DMPK/pharmacokinetics drug dispositions and PK/PD principles and practices

· Knowledge in regulatory guidance and in vitro to in vivo extrapolations (IVIVE) such as PBPK modeling and in-silico ADME predictions

· Experience conducting in vitro assays with radioisotope and fluorescent labeled compound is required

· Working experience with primary hepatocytes, 3D or co-culture models, is a plus

· Strong communication and collaboration skills with flexibility to operate in a team environment.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html 

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