Senior Associate Scientist, Analytical Chemistry - Parabilis Medicines

Why join us?

Parabilis Medicines (formerly FogPharma) is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis is headquartered in Cambridge, Mass.

What's the opportunity?

We are seeking an enthusiastic, highly motivated, detail-oriented and flexible individual with proficient analytical and purification experience to work within our Discovery Sciences group. The successful candidate will play a crucial role by using state-of-the-art automated instrumentation to deliver high quality data and high purity product in all our discovery programs as well as adaptability to work in a fast-paced environment. Moreover, the candidate will help to maintain all analytical and prep systems in the chemistry lab. This role, reporting to the head of our purification group, requires excellent organization, time management, problem solving, and communication skills.

Responsibilities

• Analytical and preparation method development
• Evaluate compounds physiochemical properties (solubility, stability, concentration measurement, logD,) with UV spectroscopy, HPLC, and mass spectrometry techniques.
• Integrate and report results to guide new compound design in our therapeutic programs.
• Synthetic peptide purification

What you'll need to be successful:

• B.S with 5+ years' experience in the pharmaceutical or biotech industry
• Expertise in reverse phase UV-triggered/Mass-directed HPLC chromatography for purification of peptides/peptide conjugates in milligram/multi-milligram amounts, in support of internal discovery efforts
• High comfort level with working in a fast-paced environment providing compound purification, characterization, and analysis in support of weekly assays
• Assessment of physiochemical properties of peptides e.g. solubility, chemical/thermal stability, and aggregation, in support of internal discovery efforts
• Experience troubleshooting and maintaining equipment in a fast-paced environment
• Experience/familiarity with solid-phase peptide synthesis is plus
• Work with minimal supervision to achieve personal objectives, while constantly realigning to meet evolving organizational needs.
• Experience in analytical QC or R&D lab using HPLC analysis and Empower/Masslynx, is strongly preferred.
• Excellent verbal and written communication skills
• Strong analytical development and problem-solving skills.
• This position requires flexibility with changing priorities.
• Ability to work on-site and attend in-person meetings.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com