Senior Associate Scientist Molecular Biology, Discovery Cardiovascular - Bristol Myers Squibb
Brisbane, CA
About the Job
Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
BMS Overview
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Immunology and Cardiovascular Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal engine of invention that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Further, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
Position Responsibilities
BMS seeks a highly motivated, creative, and collaborative Molecular and/or Cellular Biologist to join our Cardiovascular Discovery Biology team. This person will support research efforts to discover and develop novel therapies for the treatment of serious cardiovascular disease, including genetic cardiomyopathies and heart failure. The successful candidate will work collaboratively with teams in Biochemistry/Biophysics, Cell Biology, Lead Discovery and Optimization (LDO) to support BMS's Cardiovascular Research and Early Discovery efforts. Research will be aimed at establishment and validation of cellular models for novel therapeutic targets, and development of cellular assays for high throughput screening. The candidate will be a highly motivated individual with extensive experience in iPSC handling and cardiomyogenic differentiation, molecular and cellular biology techniques, gene expression modulation and cellular assay development. Previous experience with cell line engineering, and HTS screening methodologies will be highly desirable. This position provides an exciting opportunity to be a part of and grow with a key discovery function within the CV Discovery Biology Department.
In the role as a Senior Associate Scientist within Molecular and Cellular Technology, the ideal candidate will:
+ Perform standard cell culture support including maintenance and cardiogenic differentiation of iPSC lines
+ Support iPSC-CM differentiation and manufacturing towards generating disease models and supporting screening campaigns.
+ Broad range of molecular and cellular biology methods to interrogate and validate iPSC disease models and novel therapeutic targets/hypotheses.
+ Work closely with our discovery biology and LDO teams to develop and optimize HTS cell-based biological and validation assays.
+ Support gene-editing of mammalian cells, including iPSCs, towards generating disease models.
+ Prepare reports, publications and present to senior management and cross-functional teams.
+ Support some lab management duties as assigned.
Basic Qualifications:
+ Bachelor's Degree
+ 4+ years of industry experience
OR
+ Master's Degree
+ 2+ years of industry experience
Preferred Qualifications:
+ Extensive hands-on experience in cell biology and cellular assays including iPSC line maintenance and cardiogenic differentiation as well as functional assessment of healthy and diseased iPSC-CMs is highly desirable.
+ Strong experience with cellular and molecular biology methodologies including cytotoxicity assays, gene expression analysis, RNAi technologies and immunocytochemistry.
+ Hands on experience with methodologies for functional assessment of iPSC-CMs (contractility, electrophysiology, metabolic properties) is strongly preferred
+ Experience with CRISPR/Cas9 gene editing technologies is desirable.
For CA, based candidates only: The starting compensation for this job is a range from $83,000 - $104,000, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.
Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit http://careers.bms.com/life-at-bms/
Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
At BMS, our employees are committed to the following values:
Integrity - We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
Innovation - We pursue disruptive and bold solutions for patients
Urgency - We move together with speed and quality because patients are waiting
Passion - Our dedication to learning and excellence helps us to deliver exceptional results
Accountability - We all own BMS' success and strive to be transparent and deliver on our commitments
Inclusion - We embrace diversity and foster an environment where we can all work together at our full potential
Why You Should Apply
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Company: Bristol-Myers Squibb
Req Number: R1585163
Updated: 2024-09-23 06:52:23.360 UTC
Location: Brisbane-CA
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .
BMS Overview
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Immunology and Cardiovascular Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal engine of invention that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Further, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.
Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
Position Responsibilities
BMS seeks a highly motivated, creative, and collaborative Molecular and/or Cellular Biologist to join our Cardiovascular Discovery Biology team. This person will support research efforts to discover and develop novel therapies for the treatment of serious cardiovascular disease, including genetic cardiomyopathies and heart failure. The successful candidate will work collaboratively with teams in Biochemistry/Biophysics, Cell Biology, Lead Discovery and Optimization (LDO) to support BMS's Cardiovascular Research and Early Discovery efforts. Research will be aimed at establishment and validation of cellular models for novel therapeutic targets, and development of cellular assays for high throughput screening. The candidate will be a highly motivated individual with extensive experience in iPSC handling and cardiomyogenic differentiation, molecular and cellular biology techniques, gene expression modulation and cellular assay development. Previous experience with cell line engineering, and HTS screening methodologies will be highly desirable. This position provides an exciting opportunity to be a part of and grow with a key discovery function within the CV Discovery Biology Department.
In the role as a Senior Associate Scientist within Molecular and Cellular Technology, the ideal candidate will:
+ Perform standard cell culture support including maintenance and cardiogenic differentiation of iPSC lines
+ Support iPSC-CM differentiation and manufacturing towards generating disease models and supporting screening campaigns.
+ Broad range of molecular and cellular biology methods to interrogate and validate iPSC disease models and novel therapeutic targets/hypotheses.
+ Work closely with our discovery biology and LDO teams to develop and optimize HTS cell-based biological and validation assays.
+ Support gene-editing of mammalian cells, including iPSCs, towards generating disease models.
+ Prepare reports, publications and present to senior management and cross-functional teams.
+ Support some lab management duties as assigned.
Basic Qualifications:
+ Bachelor's Degree
+ 4+ years of industry experience
OR
+ Master's Degree
+ 2+ years of industry experience
Preferred Qualifications:
+ Extensive hands-on experience in cell biology and cellular assays including iPSC line maintenance and cardiogenic differentiation as well as functional assessment of healthy and diseased iPSC-CMs is highly desirable.
+ Strong experience with cellular and molecular biology methodologies including cytotoxicity assays, gene expression analysis, RNAi technologies and immunocytochemistry.
+ Hands on experience with methodologies for functional assessment of iPSC-CMs (contractility, electrophysiology, metabolic properties) is strongly preferred
+ Experience with CRISPR/Cas9 gene editing technologies is desirable.
For CA, based candidates only: The starting compensation for this job is a range from $83,000 - $104,000, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.
Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit http://careers.bms.com/life-at-bms/
Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
At BMS, our employees are committed to the following values:
Integrity - We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
Innovation - We pursue disruptive and bold solutions for patients
Urgency - We move together with speed and quality because patients are waiting
Passion - Our dedication to learning and excellence helps us to deliver exceptional results
Accountability - We all own BMS' success and strive to be transparent and deliver on our commitments
Inclusion - We embrace diversity and foster an environment where we can all work together at our full potential
Why You Should Apply
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Company: Bristol-Myers Squibb
Req Number: R1585163
Updated: 2024-09-23 06:52:23.360 UTC
Location: Brisbane-CA
Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.
Source : Bristol Myers Squibb
