Senior Principal Scientist - PKDM (Small Molecule Project Team Representative) at Amgen

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Senior Principal Scientist - PKDM (Small Molecule Project Team Representative)

What you will do

Lets do this. Lets change the world. In this vital role you will serve as a project team representative focused on small molecule (SM) programs. You will characterize the absorption, distribution, metabolism, excretion (ADME) and pharmacokinetic (PK) properties of SM therapeutic drug candidates to achieve their full pharmacological potential. In this role, your core responsibilities include:

• Serving as a functional PKDM representative and subject matter expert on the ADME/PK of small molecule therapeutics, collaborating with scientists across our PKDM scientific community
• Leveraging specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making
• Planning and executing mechanistic ADME/PK analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics to optimize dose selection and preclinical study designs.
• Contributing to the analysis of pre-clinical ADME and PK data for IND and NDA filings and documenting these analyses in appropriate reports
• Building close relationships with partner functions and therapeutic areas

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a subject matter expert with these qualifications.

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience

Masters degree and 6 years of directly related experience

Bachelors degree and 8 years of directly related experience

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training
• The ideal candidate will have a strong background serving as a PKDM functional team representative for discovery or development programs, preferably across therapeutic areas
• Candidate should have solid technical experience with the application of SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects
• Ability to drive the progression of SM discovery and development within project teams
• Lead development of scientific strategy across PKDM initiatives with a focus on development of mechanistic ADME platforms to aid in translation.
• Establish SM workflows for PKDM scientists.
• Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK
• Experience in supporting preclinical components of regulatory documentations.
• Excellent interpersonal, technical, and communication skills to lead cross-functional teams
• Past experience as a laboratory scientist in a pharma or biotech environment
• Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills
• Record of scientific contributions through peer-reviewed articles and external presentations

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.