About Talus Bio

Talus Bioscience, a venture-backed early-stage biotechnology company, is at the forefront of developing innovative therapies for incurable cancers. Driven by the belief that "nothing is undruggable," we harness cutting-edge proteomics and AI during the initial stages of discovery to unlock previously inaccessible targets in cancer.

Exciting opportunities await at Talus Bio - your chance to be part of something transformative!

Senior Research Associate Job Description

Talus Bio is looking for a Senior Research Associate (Sr RA) to join our team full-time in our Seattle office reporting to Dr. Lindsay Pino, Co-Founder and CTO.

This person will work directly with the platform and proteomics team of Talus Bio and will be naturally curious, results-driven, and eager to work in a small preclinical biotech environment.

This individual will play a critical role in developing, optimizing, and executing mass spectrometry-based workflows for proteomics research. The successful candidate will have experience in proteomics, including sample preparation, cell culture, operating LC-MS instrumentation, and mass spectrometry data analysis.

Responsibilities

• LC-MS Operation & Maintenance: Operate, maintain, and troubleshoot mass spectrometers (Orbitrap and time-of flight) and liquid chromatography systems
• Sample Preparation: Execute protocols for protein extraction, digestion (e.g., trypsin), and clean-up for LC-MS/MS analysis
• Proteomics Analysis: Conduct complex proteomics experiments, including DIA, DDA, and PRM approaches
• Method Development: Assist in the development and optimization of proteomics methods, including sample preparation and LC-MS methods
• Data Analysis & Interpretation: Analyze proteomics data using software (e.g., Skyline, EncyclopeDIA, etc.) and bioinformatics tools to identify changes in protein and peptide expression
• Collaborative Research: Work closely with cross-functional teams to design and execute experiments and interpret results
• Documentation & Reporting: Maintain detailed experimental records, analyze and interpret data, and present findings at internal meetings and external conferences

Qualifications

Required

• Education and Experience Requirements: BS degree in biology, chemistry, or a related field with 3 years of relevant experience; or a MS degree with 1 year of experience in proteomics and mass spectrometry
• Mass Spectrometry Experience: Significant hands-on experience withLC-MS/MS systems (e.g., Orbitrap, Q-TOF), including operation, maintenance, and troubleshooting
• Sample Preparation Skills: Expertise in cell culture, protein extraction, digestion, and peptide clean-up for MS analysis
• Data Analysis Tools: Proficiency with proteomics data analysis software (e.g., Skyline) and solid understanding of the analysis of proteomics data
• Technical Problem-Solving: Demonstrated ability to troubleshoot instrumentation issues and optimize methods for challenging samples
• Communication Skills: Excellent verbal and written communication skills, with the ability to present complex data clearly to both technical and non-technical audiences
• Must have authorization to legally work in the US.

Preferred

• LC-MS Method Development: Experience in developingLC-MS methods for proteomics, including DDA, DIA, or PRM methods
• Automation Skills: Familiarity with automated sample preparation systems and high-throughput workflows
• Bioinformatics Integration: Basic knowledge of a coding language (R or Python) for interpreting and presenting proteomics results

Our Commitment to Diversity & Inclusion

Talus Bio is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contractors with diverse backgrounds enables Talus Bio to better meet our mission and serve healthcare communities around the world. We recognize that opportunities in the life sciences have historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We welcome all people including cisgender, transgender, agender, and intersex and are inclusive of non-binary folx. We strongly encourage individuals with these identities to apply.

Salary and Benefits

The salary range for this role is $80,000 - $100,000/year.

Despite being a small preclinical biotech, Talus Bio's first priority is the safety and well-being of all our employees and their families, both inside and outside of the lab. As part of this commitment, we have put a great deal of thought and care into developing a cost-effective and comprehensive benefits package for our team.

Our benefits package includes but is not limited to the following:

• Medical/dental/vision insurance with 100% company-paid premiums for employees and 50% company-paid for dependents
• $112/month commuter and transportation reimbursement program
• 401(k) plan with a 4% Talus Bio contribution (regardless of employee contribution)
• Basic Life and AD&D Insurance
• 4 weeks of paid time off PLUS a paid end-of-year shutdown between Christmas Day and New Year's day
• 10 paid holidays
• Weekly meals, snacks, and drinks
• Flexible working hours
• Flexible working environment and schedule
• Yearly company retreat and quarterly company events

Talus Bioscience, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.