Senior Scientist- Cell Therapy (Cambridge, MA) at Regeneron Pharmaceuticals, Inc.

We are seeking a highly skilled and passionate Senior Scientist to support Regeneron Cell Medicine (RCM) mission to bring innovative cell therapy products to patients. This role will be critical to advance TCR- and CAR-based programs, as well as bring new ideas to improve our platforms and future programs.

As a Senior Scientist, a typical day might include:

• Leveraging molecular biology techniques to design constructs, clone, and generate lentiviral vectors using proprietary platform technology

• Designing and carrying out experimental plans to functionally characterize TCR- and CAR-based T cell products through cell based assays and other relevant procedures to explore and validate novel cell therapy approaches.

• Maintaining detailed and timely records of experimental protocols, results, and observations.

• Identifying experimental challenges and collaborating with the team to troubleshoot technical issues and propose creative solutions to overcome obstacles.

• Stay informed about the latest scientific advancements and applying relevant technologies to improve experimental processes to enhance the efficiency and efficacy of our cell therapy research

This role might be for you if you have:

• The ability to work effectively in a team-based research environment, exhibiting leadership in the lab on day-to-day basis

• Strong problem-solving skills and capacity to think critically and innovatively

• Excellent communication and presentation skills to convey complex scientific information to diverse audiences

• Detailed oriented with a commitment to producing high-quality, reliable data

• Are excited to support and mentor junior lab members to foster scientific & technical development and ensure experimental excellence

In order to be considered for this role, you must have at least a Ph.D. in Immunology, Cancer Biology, Molecular Biology, or a related field and 0-3 years of relevant experience or a BS/MS and 8-10+ years of relevant experience. Must have hands-on experience on LV-vector construct design, cloning, vector production, and mastery of basic molecular biology techniques is required. Experience with cell-based assays and functional assays measuring T cell activation, cytokine release, proliferation, survival, and tumor cell killing required. Experience with standard readouts of tumor coculture (e.g. MSD, Luminex, ELISA, etc.) is a plus. Knowledge of standard TCR/CAR-T cells culture technique is desired. Experience developing and applying complex flow cytometry panels for the characterization of TCR/CAR-T cells preferred. Experience contributing to writing of patents and/or regulatory documents is advantageous.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)