Senior Scientist - Computational Chemistry - Insmed Incorporated

Company Description:

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion. 

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career. 

Recognitions:

 

	Named Science’s Top Employer in 2021, 2022, and 2023 Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That’s why we were named the No. 1 company to work for in the biopharma industry in Science’s Top Employers Survey for three years in a row.

 

A Certified Great Place to Work® We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma™, Best Workplaces in New York™, PEOPLE® Companies That Care, Best Workplaces for Women™, Best Workplaces for Millennials™, and Best Medium Workplaces™ lists.

Overview:We are seeking a talented and motivated Computational Scientist with expertise in Computer-Aided Drug Design (CADD) to collaborate with our cross-functional teams including Chemistry, Structural Biology, and Data Science teams to create impactful solutions in drug design and discovery. The ideal candidate will possess an understanding of the application of CADD to solve challenges that may include visualization of structure-activity relationships (SAR), ADMET predictions, off-target selectivity, and physiochemical properties. The ideal candidate will also be willing to engage with cross-functional teams seeking to expand and advance Insmed’s discovery pipeline. We are a pioneering company working on novel targets to generate first in class therapeutics impactful in rare diseases.  Responsibilities:Key Responsibilities: 

• CADD Application to enable project progression: Utilize computational chemistry tools and techniques (such as molecular docking, molecular dynamics, virtual screening, QSAR, and free energy predictions FEP) to support the design and optimization of Insmed’s small molecules pipeline from hit ID through to candidate nomination.
• Data Analysis: Analyze and interpret large datasets from molecular modelling, virtual screening, fragment screening, and protein-ligand interaction studies to provide actionable insights for drug development programs. 
• Collaborative Research: Work closely with interdisciplinary teams comprising Medicinal Chemists, Structural Biologists, Data Scientists, and external collaborators to integrate computational findings into drug discovery projects. 
• Innovation & Research: Stay abreast of the latest advancements in CADD, protein structure modelling, and artificial intelligence in the context of drug design and discovery.
• Platform Development: Collaborate with internal teams to build a responsive, data-driven computational platform that incorporates the latest computational, artificial intelligence, machine learning, and cheminformatics technologies. 

Qualifications:

• PhD with 3+ years of experience in the pharmaceutical industry or MS with equivalent qualification and experience combination is required.
• Experience using computational chemistry and cheminformatics toolkits (such as Schrödinger, MOE, Gaussian, or other industry-standard software) to solve challenges related to small molecule drug design and discovery including similarity searching, matched pair analysis, clustering, QSAR modelling, visualization of structure-activity relationships, virtual library enumeration, and fragment screening.
• Strong coding skills in Python or other scripting language, experience in using KNIME or Pipeline Pilot, and familiarity with common data science packages. 
• Demonstrated experience working in a collaborative environment with teams from Chemistry, Data Science, and Structural Biology; an ability to establish and maintain cooperative working relationships with internal and external partners.
• Experience with AI and machine learning technologies in the context of drug discovery is highly desirable. 
• Strong problem-solving and communication skills with the ability to present complex data clearly. 
• Excellent presentation skills both verbal and written.
• Highly proficient in Microsoft Office (Word, Excel, PowerPoint, Outlook)
• Must successfully exhibit Insmed’s five (5) core values of Collaboration, Accountability, Passion, Respect, and Integrity along with any other position specific competencies.

#LI-MM1Salary Range:$115,000 - $161,867 a yearCompensation & Benefits:

We’re committed to investing in every team member’s total well-being, now and in the future. We offer a competitive total-rewards package to all employees around the world, including: 

• Flexible approach to where and how we work 

• Competitive compensation package including bonus.  

• Stock options and RSU awards 

• Employee stock purchase plan 

• 401(k) plan with company match 

• Professional Judgment Vacation Policy 

• 11 paid holidays per year and Winter Break (typically between Christmas and New Year’s Day). 

  

ADDITIONAL U.S. BENEFITS: 

• Medical, dental, and vision plans 

• Company-provided short- and long-term disability plans 

• Company-provided life insurance 

• Unique offerings of pet, legal, and supplemental life insurance 

• Flexible spending accounts for medical and dependent care 

• Accident and Hospital Indemnity plans 

• Supplemental AD&D 

• Employee Assistance Program (EAP) 

• Mental Health on-line digital resource 

• On-site, no-cost fitness center at our U.S. headquarters 

• Paid time off to volunteer 

Additional Information:

Insmed Incorporated is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity, national origin, veteran status, or genetic information or any other characteristic protected by law.  

  

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address. 

  

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement. 

  

Applications are accepted for 5 calendar days from the date posted or until the position is filled.