Senior Scientist II, AbbVie Biotherapeutics at AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTubeandLinkedIn.

Key Responsibilities

• Conceive & execute novel scientific research or development that achieves projects & area goals.
• Generate new scientific proposals & lead those efforts.
• Investigate, identify, develop, & optimize new methods & techniques.
• Act as a lead in area of expertise & critically evaluate relevant scientific & regulatory advances & integrate this knowledge into research or development programs.
• Conceive & implement novel experimental approaches to answer scientific questions & enable the development of antibody drug conjugates (ADCs) for the treatment of cancer.
• Responsible for conceiving & performing studies, as well as analyzing & interpreting results & effectively communicate findings in a group setting.
• Maintain solid understanding & hands-on-experience assessing key cancer cell signaling pathways such as investigating, identifying, developing, & optimizing new methods & techniques that inform on pathway/drug mechanisms of action such as flow cytometry, biochemical assays, reporter assays, or gene over-expression/knockdown.
• Identify, develop, & optimize new methods & techniques that inform on ADC/payload mechanism of actions using flow cytometry, biochemical assays, reporter assays or gene overexpression/knockdown.
• Perform flow cytometry studies to interrogate antibody binding to cells of interest and analysis using FlowJo.
• Generate & analyze omic datasets such as scRNAseq, RNA-seq or phospho-proteomic datasets to identify pharmacodynamic (PD) or resistance biomarkers.
• Responsible for validating PD & resistance biomarker utilizing immunoblot, qRT-PCR or flow cytometry.
• Understand & adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug & radioactive compounds, GxP compliance, & animal care where applicable.
• Responsible for leading presentations at International Scientific meetings.
• Manage & oversee lower-level scientists within division.
• Conduct medium- or high- throughput compound screening to identify combination partners that are clinically actionable & demonstrate the strength of their interaction utilizing synergy calculating software

Qualifications

Must possess a PhD or foreign academic equivalent in Cancer Cell Biology, Biology, Medical Biophysics, or a highly related field of study with academic or industrial background in the following:

1. conceiving & implementing novel experimental approaches to answer scientific questions & enable the development of antibody drug conjugates (ADCs) for the treatment of cancer;
2. solid understanding & hands-on-experience assessing key cancer cell signaling pathways such as investigating, identifying, developing, & optimizing new methods & techniques that inform on pathway/drug mechanisms of action such as flow cytometry, biochemical assays, reporter assays, or gene over-expression/knockdown;
3. generating & analyzing -omic datasets such as sc-RNAseq, RNA-seq or phospho-proteomic datasets to identify pharmacodynamic (PD) or resistance biomarkers;
4. validating PD & resistance biomarker utilizing immunoblot, qRT-PCR or flow cytometry; &
5. conduct medium- or high- throughput compound screening to identify combination partners that are clinically actionable & demonstrate the strength of their interaction utilizing synergy calculating software.

Salary Range: $157,533.20 - $181,500 per year

Apply online at https://careers.abbvie.com/en. Refer to Req ID: REF26524P.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term and long-term incentive programs.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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