Senior Scientist- Immunology of Gene Therapies at Regeneron Pharmaceuticals, Inc.

We are seeking a detailed oriented and highly motivated Senior Scientist to join the Immunology team within Regeneron Genetic Medicines, supporting research focused on the unique immunological challenges of gene therapy and other genetic medicines. You will spearhead projects investigating innate and adaptive immune responses to genetic medicine platforms, such as viral vectors (e.g. adeno-associated viruses/AAV), virus-like particles (VLPs), RNA therapeutics (RNAi/ASO/AOCs), lipid nanoparticles (LNP), and other next-generation modalities. In conjunction with these studies, you will develop and evaluate novel immunomodulation and immune tolerance technologies designed to manage undesired anti-drug, anti-vector, and anti-transgene immune responses. This work will also use Regenerons core suite of technologies, including VelocImmune-derived fully-human antibodies and VelociGene mouse models.

As a Senior Scientist, a typical day might include:

• Independently planning and carrying out ex vivo and in vitro studies evaluating immune responses to genetic medicine platforms

• Assisting with (and/or independently driving) in vivo studies evaluating immunomodulation/immune tolerance therapeutics and new genetic medicine modalities

• Isolating and culturing leukocytes from tissues (mice) and peripheral blood mononuclear cells (mice, non-human primates, humans)

• Conducting immune phenotyping and functional assays, including multicolor flow cytometry (10+ colors), ICS, ELISpot, proliferation assays, and cytokine ELISA/MSD

• Interpreting, collating, and presenting results at group and departmental meetings

• Keeping up-to-date with relevant scientific literature

This role might be for you if you:

• Are passionate about understanding immune-related challenges of gene therapy/genetic medicines

• Enjoy working in an innovative and highly collaborative environment

• Are adaptable and able to shift priorities and project focuses as needed

• Have strong organizational, time-management, and communication skills

In order to be considered for this role, you must have at least a Ph.D. and 0-2 years of relevant experience or a BS/MS in Biology and 8-10+ years of relevant experience in immunology or related field. We need someone with experience with ex-vivo immunological assays, including multicolor flow cytometry (10+ colors). Experience with in-vivo immunology, including mouse handling and procedures such as bleeds and injections including SQ and IV is highly preferred but not required. Experience working with genetic medicines is a plus. The ability to work collaboratively and rapidly adapt to changing priorities is essential.

We hope you will join us in making next-generation genetic medicines a reality!

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)