Senior Scientist, Next Generation Sequencing - AlivaMab Discovery Services

AlivaMab Biologics is seeking an outstanding individual to join the Antibody Engineering Team.  The successful applicant will be responsible for enabling antibody discovery and engineering projects through conduct and oversight of Next-Generation Sequencing (NGS) workflows using various sources including, but not limited to, hybridomas, single B-cells, immune repertoires, and phage libraries and subsequent data analyses to thoroughly examine antibody repertoires, broadening our understanding of sequence and functional diversity and expediting the discovery of promising leads. The individual will also have the opportunity and is expected to contribute to broader technology development and antibody engineering in collaboration with cross-functional teams, working closely with scientists in the Protein Sciences, Antibody Engineering, Antibody Discovery, and Project Management teams. This position will report to the Associate Director of Antibody Engineering.

AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics, and developability, with expanding capabilities for engineering advanced modalities, including multispecifics, single-domain human VH antibodies, and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

Responsibilities

• Maintain a robust next-generation sequencing workflow for efficient recovery of antibody variable region sequences from in vivo and in vitro sources using the Illumina MiSeq platform
• Perform data analyses and report generation of NGS data sets, comprising sequences of antibody variable region and assessments of immune repertoires to meet timelines
• Ability to understand and troubleshoot NGS-related activities to produce intelligible and interpretable data, consistent with biology and the needs for successful, efficient biologics drug discovery
• Continuous improvement of NGS workflows, including library generation, sequencing using Illumina MiSeq platforms, and library QC and analyses
• Development of innovative solutions for sequencing and molecular biology challenges
• Identify relevant bioinformatic tools and develop optimal bioinformatic workflows for data analyses
• Closely collaborate and promptly communicate with stakeholders and cross-functional teammates, actively contributing to the discovery of the next generation of biologics drugs and the development of new platform technologies
• Train and mentor junior scientific staff on relevant workflows and data analyses.
• Present data at team meetings to internal and external stakeholders.
• Generate, organize, and maintain meticulous records on all conducted experiments using Electronic Lab Notebook and generate SOPs

Qualifications

Key Skills and Requirements:

• PhD. in Molecular Biology, Biochemistry, Immunology, Cell Biology, or related Life Sciences
• 5+ years of experience in biotech/pharma or in an academic setting focused on relevant activities around next-generation sequencing
• Strong foundation in molecular biology techniques, including DNA and RNA purification and quantification, PCR, RT-PCR, and NGS library preparation and QC
• Hands-on experience running sequencing libraries on the next-generation sequencing Illumina MiSeq platform
• Understanding of the biology of the human immune repertoire and immunoglobulin genes
• Familiarity with basic bioinformatics
• Extensive experience with sequence analyses from NGS data sets comprising antibody sequences
• Experience with single-cell sequencing workflows, such as 10X Genomics, is a plus
• Excellent troubleshooting and problem-solving skills
• Meticulous attention to detail, planning, and organizational skills
• Ability to manage multiple projects simultaneously
• History of timeline-driven delivery
• Excellent communicator, highly effective in interacting with key internal and external stakeholders
• Team player and builder, possessing great coaching skills
• High functioning in an environment dedicated to exceptional quality and integrity

About AlivaMab Biologics

AlivaMab Biologics sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners’ design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics, and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team’s experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.

AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

The salary range for this position considers various factors, including skills, experience, training, certifications, and organizational needs. Note that this range does not reflect any geographic adjustments based on the location where the role will be based. At AlivaMab Biologics, it is uncommon for a new hire to start at or near the top of the salary range, as compensation is tailored to each individual’s circumstances. The current estimated range is $145,000 – $174,500, plus a bonus target, benefits, and equity.

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