Director, Disease Biology (Cell Biology/Small Molecule) - Septerna

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company's Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.

For more information see: www.septerna.com.

• Design and execute in vitro and ex vivo studies to advance therapeutic programs
• Generate, analyze, and interpret complex data to establish functional PK/PD and efficacy relationships and elucidate therapeutic mechanism of action for leads drug.
•  Serve as Disease Biology lead on multiple project teams, conduct and trouble-shoot experiments, analyze and interpret data and work cross functionally with colleagues to identify and mitigate risks and effectively advance therapeutic programs
• Help build complex in vitro and ex vivo research and development capabilities
• Author and review protocols, study reports, and regulatory documents to enable IND and other regulatory filings
• Follow all company policies/practices, and maintain accurate records and notebooks

• PhD Endocrinology, Physiology, Diabetes/Obesity, Immunology / Inflammation, or Metabolic Disease, or related biological science (MSc/BSs with relevant years of experience)
• At least 12 years direct hands-on experience in therapeutic development leveraging indication specific functional disease models in biotechnology and pharmaceutical industries (MSc with at least 15 years, BSc with at least 20years)
• Experience with cell-based assays, ELISA, MSD, qPCR, RNA-seq, microscopy, histology/pathology (e.g. IF/IHC/ISH), and/or flowcytometry
• Ability to be hands on and working in the lab, manage scientists, write protocols, execute studies leveraging Septerna in house capabilities or working with CROs
• Direct experimental experience with complex disease biology of diabetes, obesity or other metabolic disease
• Demonstrated expertise in building PK/PD and efficacy relationships with complex 2D/3D functional cell-based and tissue-based assays
• Leverage complex data sets to characterize therapeutic leads and establish a drug's therapeutic mechanisms of action
• Experience working on/leading project teams with functional responsibility to propose strategy, analyze, interpret, and present complex data to inform decisions
• Ability to collaborate in writing protocols, reports, and regulatory documents
• Experience working with vendors and CROs to execute studies, analyze data, and generate reports in a timely manner
• Experience authoring study protocols, reports, and/or regulatory documents including IBs, IND filings, CSRs, and/or NDAs
• Outstanding communication skills with demonstrated ability to make effective presentations in a broad range of settings
• Detail-oriented and organized, with strong interpersonal skills for clear and effective communication

• Experience with therapeutics programs which have yielded drugs entering clinical development in one or more of the following therapeutic areas:  endocrinology, diabetes / obesity, immunology / inflammation, or metabolic disease
• Experience with microscopy, confocal imaging, or similar a plus
• Experience working as a subject matter expert with complex cell-based 2D/3D culture systems or ex vivo tissue models or patient derived samples a plus
• Ability to generate, analyze and interpret multi-omic data sets
• Establish workflows, use Jupyter notebook or other platform to perform bioinformatics analysis and interpret and visualize complex data sets a plus
• Previous work leading a program in therapeutic discovery/development
• Strong statistical analysis skills and an ability to articulate findings and make recommendations from complex study results
• Experience mentoring scientists, leading cross-functional project teams, and a track record of successful management of external teams