Staff Engineer - Analytics, Viral Vector Gene Therapy Process Development at Regeneron Pharmaceuticals, Inc.

Regeneron's Preclinical Manufacturing and Process Development (PMPD) group is looking for a energetic Staff Engineer to focus on the viral vector process development. You will be responsible for analytical development and support manufacturing process development functions. In this role you will work as part of a multi-functional team to develop Adeno-Associated Virus (AAV) manufacturing processes, assays, and products. This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institution knowledge gained from working for a larger firm.

A Typical Day in the Role of Staff Engineer Might Look Like:

• Perform physicochemical characterization for all stages of viral vector products
• Support process development and production by designing and developing fast and robust assays for the characterization of AAV.
• Perform technology transfer of AAV characterization assay to external and internal GMP partners to enable clinical and commercial production of therapeutic AAV gene therapy products
• Cross-train on and provide support for upstream and downstream process development operations.
• Provide scientific expertise in theory and practice of manufacturing steps and analytical methods and mentor junior colleagues to expand team capabilities.
• Support routine sample testing for characterizing AAV safety, integrity, strength, purity and quality, get results, and onboard new technologies.
• Maintain instruments and fix instrumental/experimental problems.
• Prepare and deliver effective oral presentations in area of expertise at internal and external professional meetings.

This Job Might Be For You If You:

• Possess excellent interpersonal, verbal, and written communication skills.
• Must have strong initiative and drive to complete ambitious tasks and learn new technologies.
• Must be capable of multi-tasking, working both independently and within a team environment.
• Think critically and demonstrate problem-solving skills.

This position requires a PhD with 3-5+ years proven experience in either Chemical Engineering, Biochemical Engineering, Biochemistry, Molecular Biology, Automation Engineering, or related field. Final position level would depend on years of experience. The ideal candidate would have: A strong fundamental understanding assay development, of developing analytical methods for bioprocess characterization and a detailed understanding of statistical analysis principles used in Design of Experiments to efficiently, to optimize and characterize assays. Experience with outsourcing assays and oversight of CRO activities is a plus. Experience in high-throughput assays is a plus. Familiarity with automated liquid handlers is desired. Prior experience with AAV-based gene therapies is a plus.

• Meaningful experience with some of the following techniques is helpful: qPCR/ddPCR, ELISA-based assays, Analytical Ultracentrifuges, Benchling, Western Blots and Gel Electrophoresis, HPLC, UPLC, Mass Photometry, Dynamic and Static Light Scattering, Hamilton Liquid Handlers, Empower, UNICORN, LIMS, NGS.

#pmpdIntro To PMPD Video:

https://www.youtube.com/watch?v=pAboGKlI1zw&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=6

Intro To Viral Production Core:https://www.youtube.com/watch?v=KtR5_mKkXlo

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$124,200.00 - $202,800.00