UNIV- Postdoc- Department of Biochemistry - MUSC

Job Description SummaryPostdoctoral fellow to work full-time on understanding the functions of protein post-translational modifications in human cancers. The research will particularly focus on the regulatory mechanisms and physiological function...

Job Description Summary

Postdoctoral fellow to work full-time on understanding the functions of protein post-translational modifications in human cancers. The research will particularly focus on the regulatory mechanisms and physiological functions of arginine methyltransferases and in genomic instability and cancer progression. The goal of these studies is to explore druggable targets for cancer therapy. Studies will use a range of complementary methods including biochemistry, molecular and cellular biology, functional cell-based assays and mouse genetic models. The candidate should be highly motivated with a recent Ph.D. degree and a solid background and skills in molecular cell biology and cancer biology. Experience in signaling transduction and mouse genetics is desirable but not necessary.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type​

Regular

Cost Center

CC000954 COM BIOCHEM Operations CC

Pay Rate Type

Salary

Pay Grade

University-00

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Summary: Postdoctoral fellow to work full-time on understanding the functions of protein post-translational modifications in human cancers. The research will particularly focus on the regulatory mechanisms and physiological functions of arginine methyltransferases and in genomic instability and cancer progression. The goal of these studies is to explore druggable targets for cancer therapy. Studies will use a range of complementary methods including biochemistry, molecular and cellular biology, functional cell-based assays and mouse genetic models. The candidate should be highly motivated with a recent Ph.D. degree and a solid background and skills in molecular cell biology and cancer biology. Experience in signaling transduction and mouse genetics is desirable but not necessary.

Duties:

1. Collaborates with the PI using cell culture models to dissect the regulatory mechanisms of arginine methyltransferases and their downstream targets. These studies include cell culture, transfection, protein exaction, immunoprecipitation, western blot, cell proliferation, and colony formation.

35% of total efforts

2. Collaborates with the PI involved to design and executes experiments using state-of-the-art mouse genetic models and cells prepared form these models to study the role of arginine methyltransferases in cancer progression and metastasis. These duties include genotyping of mice, mice maintenance, mice breeding, treatment studies, monitoring for cancer development.

30% of total efforts

3. Collaborates with other lab members to generate necessary molecular reagents and perform molecular analysis, including DNA/RNA purification, plasmid construction, PCR, RT-qPCR.

15% of total efforts

4. Collaborate with the PI to prepare manuscripts and grants. Duties include keeping current with the literature, preparing figures based on data collected, writing manuscripts and sections of grants with the PI and senior team members, presenting current work in research in progress seminars, attending departmental seminars and participating in journal clubs.

10% of total efforts

5. Collaborates with other lab members to maintain the laboratory, including making buffers, equipment maintenance, cleanup of lab areas, monitoring usage and deliver of lab supplies.

10% of total efforts

MUSC Minimum Requirements:

PhD

Physical Requirements:

Ability to perform job functions in an upright position. (Continuous)

Ability to perform job functions in a seated position. (Continuous)

Ability to perform job functions while walking/mobile. (Frequent)

Ability to climb stairs. (Infrequent)

Ability to work indoors. (Continuous)

Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent)

Ability to bend at the waist. (Frequent)

Ability to twist at the waist. (Frequent)

Ability to perform 'pinching' operations. (Continuous)

Ability to fully use both hands/arms. (Continuous)

Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous)

Ability to fully use both legs. (Continuous)

Ability to reach in all directions. (Continuous)

Possess good finger dexterity. (Continuous)

Ability to maintain tactile sensory functions. (Continuous)

Ability to maintain good olfactory sensory function. (Continuous)

Ability to lift and carry 15 lbs., unassisted. (Frequent)

Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent)

Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent)

Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent)

Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent)

Ability to maintain 20/40 vision, corrected. (Continuous)

Ability to see and recognize objects close at hand. (Continuous)

Ability to see and recognize objects at a distance. (Continuous)

Ability to match or discriminate between colors. (Continuous)

Ability to determine distance/relationship between objects; depth perception. (Continuous)

Good peripheral vision capabilities. (Continuous)

Ability to maintain hearing acuity, with correction. (Continuous)

Ability to perform gross motor functions with frequent fine motor movements. (Continuous)

Ability to be qualified physically (by medical personnel) for respirator use, initially and annually.

Ability to work alone in isolated areas, such as darkrooms. (Frequent)

Additional Job Description

N/A

If you like working with energetic enthusiastic individuals, you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.

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